N-Nitrosomelatonin Enhances Photic Synchronization Of Mammalian Circadian Rhythms
Baidanoff, FM; Plano, SA; Doctorovich, F; Suárez, SA; Golombek, DA; Chiesa, JJ
HERO ID
2232433
Reference Type
Journal Article
Year
2014
Language
English
PMID
| HERO ID | 2232433 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | N-Nitrosomelatonin Enhances Photic Synchronization Of Mammalian Circadian Rhythms |
| Authors | Baidanoff, FM; Plano, SA; Doctorovich, F; Suárez, SA; Golombek, DA; Chiesa, JJ |
| Journal | Journal of Neurochemistry |
| Volume | 129 |
| Issue | 1 |
| Page Numbers | 60-71 |
| Abstract | Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a two-fold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of cFOS and PER1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-hour delay). Here we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances. This article is protected by copyright. All rights reserved. |
| Doi | 10.1111/jnc.12613 |
| Pmid | 24261470 |
| Wosid | WOS:000333135800006 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | circadian; jet lag; nitric oxide; N-nitrosomelatonin; suprachiasmatic nucleus |