Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition
Simões, HG; Asano, RY; Sales, MM; Browne, RA; Arsa, G; Motta-Santos, D; Puga, GM; Lima, LC; Campbell, CS; Franco, OL
HERO ID
2232397
Reference Type
Journal Article
Year
2013
Language
English
PMID
| HERO ID | 2232397 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Type 2 diabetes elicits lower nitric oxide, bradykinin concentration and kallikrein activity together with higher DesArg(9)-BK and reduced post-exercise hypotension compared to non-diabetic condition |
| Authors | Simões, HG; Asano, RY; Sales, MM; Browne, RA; Arsa, G; Motta-Santos, D; Puga, GM; Lima, LC; Campbell, CS; Franco, OL |
| Journal | PLoS ONE |
| Volume | 8 |
| Issue | 11 |
| Page Numbers | e80348 |
| Abstract | This study compared the plasma kallikrein activity (PKA), bradykinin concentration (BK), DesArg(9)-BK production, nitric oxide release (NO) and blood pressure (BP) response after moderate-intensity aerobic exercise performed by individuals with and without type 2 diabetes. Ten subjects with type 2 diabetes (T2D) and 10 without type 2 diabetes (ND) underwent three sessions: 1) maximal incremental test on cycle ergometer to determine lactate threshold (LT); 2) 20-min of constant-load exercise on cycle ergometer, at 90% LT and; 3) control session. BP and oxygen uptake were measured at rest and at 15, 30 and 45 min post-exercise. Venous blood samples were collected at 15 and 45 minutes of the recovery period for further analysis of PKA, BK and DesArg(9)-BK. Nitrite plus nitrate (NOx) was analyzed at 15 minutes post exercise. The ND group presented post-exercise hypotension (PEH) of systolic blood pressure and mean arterial pressure on the 90% LT session but T2D group did not. Plasma NOx increased ~24.4% for ND and ~13.8% for T2D group 15 min after the exercise session. Additionally, only ND individuals showed increases in PKA and BK in response to exercise and only T2D group showed increased DesArg(9)-BK production. It was concluded that T2D individuals presented lower PKA, BK and NOx release as well as higher DesArg(9)-BK production and reduced PEH in relation to ND participants after a single exercise session. |
| Doi | 10.1371/journal.pone.0080348 |
| Pmid | 24265812 |
| Wosid | WOS:000327252100148 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |