An occupational exposure assessment of a perfluorooctanesulfonyl fluoride production site: biomonitoring
Olsen, GW; Logan, PW; Hansen, KJ; Simpson, CA; Burris, JM; Burlew, MM; Vorarath, PP; Venkateswarlu, P; Schumpert, JC; Mandel, JH
HERO ID
2223220
Reference Type
Journal Article
Year
2003
Language
English
PMID
| HERO ID | 2223220 |
|---|---|
| In Press | No |
| Year | 2003 |
| Title | An occupational exposure assessment of a perfluorooctanesulfonyl fluoride production site: biomonitoring |
| Authors | Olsen, GW; Logan, PW; Hansen, KJ; Simpson, CA; Burris, JM; Burlew, MM; Vorarath, PP; Venkateswarlu, P; Schumpert, JC; Mandel, JH |
| Journal | AIHA Journal |
| Volume | 64 |
| Issue | 5 |
| Page Numbers | 651-659 |
| Abstract | This investigation randomly sampled a fluorochemical manufacturing employee population to determine the distribution of serum fluorochemical levels according to employees' jobs and work areas. Previous analyses of medical surveillance data have not shown significant associations between fluorochemical production employees' clinical chemistry and hematology tests and their serum PFOS and perfluorooctanoate (PFOA, C(7)F(15)COO(-)) concentrations, but may have been subject to nonparticipation bias. A random sample of the on-site film plant employee population, where fluorochemicals are not produced, determined their serum concentrations also. Of the 232 employees randomly selected for serum sampling, 186 (80%) employees participated (n=126 chemical plant; n=60 film plant). Sera samples were extracted using an ion-pairing extraction procedure and were quantitatively analyzed for seven fluorochemicals using high-pressure liquid chromatography electrospray tandem mass spectrometry methods. Geometric means (in parts per million) and 95% confidence intervals (in parentheses) of the random sample of 126 chemical plant employees were: PFOS 0.941 (0.787-1.126); PFOA 0.899 (0.722-1.120); perfluorohexanesulfonate 0.180 (0.145-0.223); N-ethyl perfluorooctanesulfonamidoacetate 0.008 (0.006-0.011); N-methyl perfluorooctanesulfonamidoacetate 0.081 (0.067-0.098); perfluorooctanesulfonamide 0.013 (0.009-0.018); and perfluorooctanesulfonamidoacetate 0.022 (0.018-0.029). These geometric means were approximately one order of magnitude higher than those observed for the film plant employees. |
| Doi | 10.1202/375.1 |
| Pmid | 14521435 |
| Wosid | WOS:000185927200014 |
| Url | <Go to ISI>://WOS:000185927200014 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: AIHA journal : a journal for the science of occupational and environmental health and safety ISSN: 1542-8117 |
| Is Public | Yes |
| Language Text | English |
| Keyword | biological monitoring; fluorochemicals; organic fluorine; perfluorooctanoate; perfluorooctanesulfonate |