Preparation of a Pseudolatex-Membrane for Ketoprofen Transdermal Drug Delivery Systems
Suksaeree, J; Charoenchai, L; Monton, C; Chusut, Tun; Sakunpak, A; Pichayakorn, W; Boonme, P
| HERO ID | 2219894 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Preparation of a Pseudolatex-Membrane for Ketoprofen Transdermal Drug Delivery Systems |
| Authors | Suksaeree, J; Charoenchai, L; Monton, C; Chusut, Tun; Sakunpak, A; Pichayakorn, W; Boonme, P |
| Journal | Industrial and Engineering Chemistry Research |
| Volume | 52 |
| Issue | 45 |
| Page Numbers | 15847-15854 |
| Abstract | Ethyl cellulose (EC) and deproteinized natural rubber latex (DNRL) were used to prepare a pseudolatex-base as a matrix membrane for ketoprofen patches. The pseudolatex-base was prepared using a homogenization and solvent removal method. Either polyvinyl alcohol or polysorbate 80 was used as surfactant and emulsifier. Polyvinyl pyrrolidone, glycerine, isopropyl palmitate, and dibutyl phthalate were used as a channeling agent, skin humectant, enhancer, and plasticizer, respectively. Ketoprofen was incorporated into the pseudolatex-base. All pseudolatex formulations were homogeneous and smooth in texture and elegant in appearance. The pH of pseudolatex formulations was 5-7, and the particle size was 487-787 nm. The viscosity and spreadability test showed the good characteristics of membrane. Stable colloidal dispersion was formed with a zeta potential of -35.18 to -51.55 mV. All pseudolatex formulations were formed into in situ membranes by solvent evaporation in a hot air oven at 70 +/- 2 degrees C. The mechanical test and moisture uptake were characterized, which significantly depended on ingredient. The in vitro release and skin permeation of ketoprofen from the pseudolatex-membrane were evaluated. The suitable pseudolatex-membrane was produced from a EC:DNRL ratio of 1:1 and provided a controlled release and suitable permeation patterns of the ketoprofen. Thus, these systems are essentially based on a matrix membrane made from polymeric pseudolatex systems. |
| Doi | 10.1021/ie402345a |
| Wosid | WOS:000327103300018 |
| Url | https://search.proquest.com/docview/2045839263?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | article; cellulose; dibutyl phthalate; drug delivery systems; emulsifiers; engineering; evaporation; glycerol; homogenization; ingredients; ketoprofen; palmitates; particle size; plasticizers; polysorbates; polyvinyl alcohol; polyvinylpyrrolidone; solvents; surfactants; texture; viscosity; zeta potential |