Study of artificial flavoring substances for mutagenicity in the salmonella/microsome, basc and micronucleus tests
Wild, D; King, MT; Gocke, E; Eckhardt, K
HERO ID
2207709
Reference Type
Journal Article
Year
1983
Language
English
PMID
| HERO ID | 2207709 |
|---|---|
| In Press | No |
| Year | 1983 |
| Title | Study of artificial flavoring substances for mutagenicity in the salmonella/microsome, basc and micronucleus tests |
| Authors | Wild, D; King, MT; Gocke, E; Eckhardt, K |
| Journal | Food and Chemical Toxicology |
| Volume | 21 |
| Issue | 6 |
| Page Numbers | 707-719 |
| Abstract | Seventy-six compounds used as artificial flavouring substances in food products were studied for mutagenic properties by the use of the Salmonella/mammalian microsome test (Ames test), Basc test on Drosophila melanogaster and micronucleus test on mouse bone marrow. The following four compounds were mutagenic in Ames tests: ethyl nitrite, ethyl 3-phenylglycidate, 6-methylquinoline and musk ambrette. Of these, ethyl nitrite and musk ambrette also induced a significant (P ⩽ 0.01) increase in sex-linked recessive lethal mutations in Drosophila. Two further compounds, ethyl 3-methyl-3-phenylglycidate and 4-n-propylanisole, appeared weakly mutagenic in Drosophila only. The result with 4-n-propylanisole was judged to be of equivocal biological significance. None of the flavouring substances induced micronuclei, i.e. cytogenetic damage in the bone marrow of mice. |
| Doi | 10.1016/0278-6915(83)90202-8 |
| Pmid | 6420251 |
| Wosid | A1983RZ21900002 |
| Url | http://www.sciencedirect.com/science/article/pii/0278691583902028 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | CE; Council of Europe; EMPG; ethyl 3-methyl-3-phenylglycidate; EPG; ethyl 3-phenylglycidate; FEMA; Flavor and Extract Manufacturers' Association; IOFI; International Organization of the Flavor Industry; SRL; sex-linked recessive lethal |
| Is Peer Review | Yes |
| Relationship(s) |
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