Mechanisms of PCBS-Induced Breast Cancer
Robertson, LW
| HERO ID | 2198663 |
|---|---|
| Year | 2000 |
| Title | Mechanisms of PCBS-Induced Breast Cancer |
| Authors | Robertson, LW |
| Volume | GRA and I |
| Abstract | For understanding the possible role of PCBs in breast cancer induction we have to 1. Unravel the mechanisms of PCB carcinogenesis, 2. Investigate whether these mechanisms occur in the breast. We found that: i. 4- chlorobiphenyl is an initiator in rat liver; ii. Human breast tissue is qualitatively able to metabolically activate PCBs similarly as the liver; iii. in mouse liver PCBs are activated to metabolites that bind to nuclear protein and DNA; the structure of the adduct still needs to be determined; iv. PCB quinone and hydroquinone metabolites bind to DNA in vitro, deplete intracellular glutathione and produce reactive oxygen species (ROS) in cells in culture; v. PCB treatment results in the activation of transcription factors, 8-OH-d and formation, and increase in lipid peroxidation derived endogenous polar DNA adducts in rat liver; vi. PCBs produce oxidative stress by redox reactions of the metabolites or/and by changes in the levels of anti-oxidant enzymes and cofactors; vii. Human breast tissue varies greatly in pro-/anti-oxidant enzyme activity. Oxidative stress could be the major factor in PCB carcinogenesis. Therefore we will analyze oxidative stress in breast tissue after PCB treatment, and try to identify enzymatic risk factors for PCB carcinogenesis in women. |
| Report Number | NTIS/02929338_a |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Govt Reports Announcements and Index ISSN: |
| Is Public | Yes |