Effect of vitamin E levels in diets on vitamin A content and lipid peroxide formation in the liver of polychlorinated biphenyls-administered rats
Ikegami, S; Saito, M; Nagayama, S; Innami, S; Nishide, E
| HERO ID | 2197696 |
|---|---|
| In Press | No |
| Year | 1980 |
| Title | Effect of vitamin E levels in diets on vitamin A content and lipid peroxide formation in the liver of polychlorinated biphenyls-administered rats |
| Authors | Ikegami, S; Saito, M; Nagayama, S; Innami, S; Nishide, E |
| Journal | The Japanese Journal of Nutrition and Dietetics |
| Volume | 38 |
| Issue | 6 |
| Page Numbers | 303-310 |
| Abstract | HEEP COPYRIGHT: BIOL ABS. Effect of dietary vitamin E levels on the depression of vitamin A storage and lipid peroxide formation in rats given PCB (polychlorinated biphenyls) was studied. Weanling male Sprague Dawley rats were fed experimental diets containing 0, 0.01 and 0.025% PCB and 10 and 25 mg% vitamin E (as alpha-tocopheryl acetate) for 10 days. PCB and vitamin E added to the diets showed no significant effect on body weight gain. Hepatic hypertrophy was observed as PCB content in the diet increased but it was not depressed by ingestion of diet containing 25 mg% vitamin E. PCB administration with vitamin E at a higher level (25 mg%) enhanced concentrations of vitamin E in the liver. No significant difference in vitamin E content of the liver was observed between animals fed diets containing 10 mg% and 25 mg% vitamin E without PCB. Vitamin A content in the liver decreased with increased PCB in diet and a larger supply of dietary vitamin E did not prevent the depression of vitamin A storage. TBA value in the liver of rats fed a 0.025% PCB diet increased significantly and the value was not depressed by the larger supply of dietary vitamin E (2.5-fold usual level). Glutathione peroxidase activities in the whole liver were not varied by PCB administration and levels of dietary vitamin E. Activities/gram of the tissue were lowered in the liver enlarged by PCB. The larger supply of dietary vitamin E depressed the content of cytochrome P-450 in the liver microsome which was significantly induced by ingestion of PCB. |
| Doi | 10.5264/eiyogakuzashi.38.303 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: JPN J NUTR ISSN: |
| Is Public | Yes |