Effects of dietary lipids on growth and lipid metabolism in rats given polychlorinated biphenyls
Innami, S; Nakamura, A; Ono, S; Nagayama, S
| HERO ID | 2197503 |
|---|---|
| In Press | No |
| Year | 1978 |
| Title | Effects of dietary lipids on growth and lipid metabolism in rats given polychlorinated biphenyls |
| Authors | Innami, S; Nakamura, A; Ono, S; Nagayama, S |
| Journal | The Japanese Journal of Nutrition and Dietetics |
| Volume | 36 |
| Issue | 5 |
| Page Numbers | 215-224 |
| Abstract | HEEP COPYRIGHT: BIOL ABS. The interaction between PCB (polychlorinated biphenyl) toxicity and dietary fats was examined. Weanling Sprague Dawley male rats received experimental diets containing 0.1% PCB in which the tetrachloride isomer was dominant. When rats were fed the 0.1% PCB diets containing different fats at 10% levels for 6 wk, the growth rate of the lard group was significantly lower than that of the other 3 groups, soybean oil, olive oil and crisco. The weight gains of experimental animals given 0.1% PCB for 6 wk varied by the different fat levels which were kept at 5% and 25% in the diet. The growth rates of the 5% soybean oil group and 5% lard group were lower than that of the 25% fat groups. The weight gain of the 5% lard group was the lowest and only 4 of 9 rats in this group survived over 38 days after PCB treatments started. The significant increase of phospholipid and cholesterol concentration in the serum and liver of rats given 0.1% PCB was shown regardless of the quality and level of dietary fats. Triglyceride concentration in the serum and liver of the PCB-fed group tended to decrease, but it tended to increase in the liver of rats fed a 0.1% PCB diet with 25% level of soybean oil. Unmetabolized PCB accumulated more in the liver of 25% fat groups than that of 5% fat groups. The possible mechanism in the severe toxic effect of PCB in low lard group was discussed in connection with the relative increase of linoleic acid requirement followed by phospholipid elevation in PCB-treated animals. |
| Doi | 10.5264/eiyogakuzashi.36.215 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: JPN J NUTR ISSN: |
| Is Public | Yes |