Toxicology of selected symmetrical hexachlorobiphenyl isomers I. Biological responses in chicks and mice
Biocca, M; Moore, JA; Gupta, BN; Mckinney, JD
HERO ID
2192239
Reference Type
Meetings & Symposia
Year
1975
Language
English
| HERO ID | 2192239 |
|---|---|
| Year | 1975 |
| Title | Toxicology of selected symmetrical hexachlorobiphenyl isomers I. Biological responses in chicks and mice |
| Authors | Biocca, M; Moore, JA; Gupta, BN; Mckinney, JD |
| Abstract | One-day-old cockerels were fed: (J) 3,10,30,100, and 300 ppm of 3,4,5,3',4',5'-hexachlorobiphenvl (HCB); (II) 400 ppm of 2,3,4,2',3',4'-HCB; (III) 400 ppm of 2,4,5,2',4',5'-HCB; (IV) 400 ppm of 2,3,6,2',3',6'-HCB; and (V) 400 ppm of 2,4,6,2',4',6'-HCB. Surviving chicks were sacrificed at 21 days. Male mice were fed 10,30, 100 and 300 ppm of three of the above isomers (I, III, V), and survivors were sacrificed at 28 days, HCB's levels in adipose tissue and liver were determined. There were variations among the isomers as to dose and pathologic effects. Isomer (I) showed the greatest effect of those studied on mortality, body weight gain, liver, thymus, and spleen; it also attained the highest tissue concentration. It was the only isomer which produced porphyrin accumulation; and, in the chicks, produced hydropericardium, ascites, and edema. The decreasing order of overall toxicity was I >> V > II, III, I V. A general similarity of response was observed in both chicks and mice. |
| Dupe Override | No |
| Conference Location | Chicago, Illinois, USA |
| Conference Name | Proceedings of the National Conference on Polychlorinated Biphenyls |
| Conference Date | November 19-21, 1975 |
| Is Public | Yes |
| Language Text | English |