Prenatal exposure to a low dose of 4-hydroxy-2 ', 3 ', 3 ', 4 ', 5 '-pentachlorobiphenyl increases emotional behaviors in mice
Soeda, F; Kaitsuka, T; Shirasaki, T; Takahama, K
HERO ID
2184699
Reference Type
Journal Article
Year
2005
Language
English
| HERO ID | 2184699 |
|---|---|
| In Press | No |
| Year | 2005 |
| Title | Prenatal exposure to a low dose of 4-hydroxy-2 ', 3 ', 3 ', 4 ', 5 '-pentachlorobiphenyl increases emotional behaviors in mice |
| Authors | Soeda, F; Kaitsuka, T; Shirasaki, T; Takahama, K |
| Journal | Journal of Health Science |
| Volume | 51 |
| Issue | 4 |
| Page Numbers | 488-491 |
| Abstract | Hydroxylated polychlorinated biphenyl (OH-PCB) is a major metabolite of PCB, which is an endocrine disruptor. In this study, we investigated the neurobehavioral effects of prenatal exposure to a very low dose of OH-PCB (4-hydroxy-2', 3, 3', 4', 5'-pentachlorobiphenyl, 4-OH-pentaCB) in mice. 4-OH-pentaCB, dissolved in corn oil, was orally given at 0.1 ug/30 ul/animal/day to pregnant mice from gestation days 11 to 17. In the open field test, the number of ambulation and rearing drastically increased among 4-OH-pentaCB exposed mice compared with the control. However, 4-OH-pentaCB exposure had no effect on passive avoidance. These results suggest that an extremely low dose of 4-OH-pentaCB may selectively disrupt neurobehavioral functions involved in ambulation and rearing in mice. |
| Wosid | WOS:000231320200013 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | hydroxylated polychlorinated biphenyl; ambulation; endocrine disruptor |