Polychlorobiphenyls (PCB) induced fetopathy. II. Experimental studies: possible placental transfer of polychlorobiphenyls in rats
Kato, T; Yakushiji, M; Tsuda, H; Arima, A; Takahashi, K
HERO ID
2181050
Reference Type
Journal Article
Year
1972
Language
English
PMID
| HERO ID | 2181050 |
|---|---|
| In Press | No |
| Year | 1972 |
| Title | Polychlorobiphenyls (PCB) induced fetopathy. II. Experimental studies: possible placental transfer of polychlorobiphenyls in rats |
| Authors | Kato, T; Yakushiji, M; Tsuda, H; Arima, A; Takahashi, K |
| Journal | Kurume Medical Journal |
| Volume | 19 |
| Issue | 1 |
| Page Numbers | 53-59 |
| Abstract | Fetopathic effects of polychlorinated biphenyls (PCBs) were studied in rats. The purpose of the study was to investigate the possibility that PCBs could be transferred transplacentally from the mother to the fetus. Pregnant Wistar-rats were administered 0, 25, 75, 225, or 675 milligrams per kilogram (mg/kg) Kanechlor-400 (12737870) (KC), a commercial PCB preparation, by stomach tube on day 1 of gestation. The effects on the course of pregnancy and delivery were evaluated. Mortality was recorded, and selected dams were necropsied. After birth, selected offspring were examined for malformations. Growth was monitored up to about 60 days of age. Pregnant rats were administered tritium (H-3) labeled KC shortly before delivery. Eighteen or 48 hours later, the dams were killed, and maternal and fetal tissues were assayed for H-3 activity. All dams given 225 and 675mg/kg KC died on day 10. An increasing trend toward stillbirth and postnatal death was seen. Dose/dependent histopathological changes were found in maternal livers and kidneys. These included swollen hepatocytes and partial degeneration in the liver, and tubular dilatation and congestion in the kidneys. Follicular atrophy in the spleen and pulmonary edema were seen in the 225 or 675mg/kg group. No fetal abnormalities were found. H-3 activity was found in the placenta, amnion, and fetal body. The authors suggest that KC can be transferred transplacentally, even though no histopathological changes were found in the fetuses. |
| Pmid | 4622486 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: KURUME MED J 19 ISSN: |
| Is Public | Yes |
| Language Text | English |
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