Effects of ethanol and polychlorinated-biphenyls in combination on ascorbic-acid metabolism, liver drug-metabolizing-enzymes, and lipid-metabolism in rats
Mochizuki, S; Watanabe, Y; Kato, K; Yoshida, A
HERO ID
2176964
Reference Type
Journal Article
Year
1992
Language
English
| HERO ID | 2176964 |
|---|---|
| In Press | No |
| Year | 1992 |
| Title | Effects of ethanol and polychlorinated-biphenyls in combination on ascorbic-acid metabolism, liver drug-metabolizing-enzymes, and lipid-metabolism in rats |
| Authors | Mochizuki, S; Watanabe, Y; Kato, K; Yoshida, A |
| Journal | Bioscience, Biotechnology, and Biochemistry |
| Volume | 56 |
| Issue | 12 |
| Page Numbers | 2037-2040 |
| Abstract | BIOSIS COPYRIGHT: BIOL ABS. We investigated the combined effects of ethanol and polychlorinated biphenyls (PCB) on ascorbic acid metabolism, liver drug-metabolizing enzymes, and lipid metabolism in rats fed on a diet containing by 36% by energy of ethanol and 0.005% of PCB, either singly or in combination, for 49 days. Ethanol and PCB given together synergistically affected the amount of ascorbic acid excreted in the urine and the serum concentration of ascorbic acid. This synergistic effect was also observed in the activity of aniline hydroxylase in the liver. Ethanol and PCB given together seem to have had different effects on lipid metabolism. These results suggest that the effect of ethanol on the metabolism of ascorbic acid and of drugs may be enhanced by combined administration with PCB, and that the ascorbic acid deficiency and/or modification of the drug metabolism may become more serious. |
| Doi | 10.1271/bbb.56.2037 |
| Wosid | WOS:A1992KG82800028 |
| Url | <Go to ISI>://WOS:A1992KG82800028 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |