Parental concentration of polychlorinated biphenyl in Michigan anglers and altered Sex Ratio in offspring
Karmaus, W; Kuang, S; Cameron, L
| HERO ID | 2169385 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2001 |
| Title | Parental concentration of polychlorinated biphenyl in Michigan anglers and altered Sex Ratio in offspring |
| Authors | Karmaus, W; Kuang, S; Cameron, L |
| Journal | American Journal of Epidemiology |
| Volume | 153 |
| Issue | 11 |
| Page Numbers | S133-S133 |
| Abstract | Contamination of Great Lakes sport fish generated three surveys to assess the Polychlorinated Biphenyl (PCB) body burden in Michigan anglers in 1973-74, 1979-82, and 1989-91. This cohort included a total of 1,177 individuals with serum PCB determinations. Serum PCB levels were determined using Webb-McCall packed column gas chromatography technique. In 2000, we re-contacted the cohort and conducted telephone interviews about their children's birth information. We estimated the Sex Ratio (SR) for parental PCB level using logistic regression. We mailed 886 letters to separate addresses, families and/or individuals representing 621 original families. Final participants were comprised of 412 families with 647 individual parents. The total number of children was 1,205. We then restricted the offspring sample (1) to those born after 1963 (n = 475) and (2) to those born within 10 years of both parental PCB measurements (n = 257). If paternal PCB levels exceeded 8 ug/L, the SR of fathering a boy was increased (SR 2.08 (95% CI 1.09-3.98)) for children born after 1963 and controlling for the maternal exposure. The association did not change when the analysis was restricted to offspring born within 10 years of both the parental measurements. For maternal PCB levels of 8 ug/L and more, the sex ratio of giving birth to a boy was decreased. We conclude that paternal exposure to PCB is linked to a higher chance of male offspring and maternal exposure to a lower chance. These findings are opposite to those reported for dioxin. |
| Wosid | WOS:000169006400449 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |