Polychlorinated biphenyl (PCB) effects on hepatic mixed function oxidases and porphyria in birds—II. American kestrel
Elliott, JE; Kennedy, SW; Jeffrey, D; Shutt, L
HERO ID
2160912
Reference Type
Journal Article
Year
1991
Language
English
| HERO ID | 2160912 |
|---|---|
| In Press | No |
| Year | 1991 |
| Title | Polychlorinated biphenyl (PCB) effects on hepatic mixed function oxidases and porphyria in birds—II. American kestrel |
| Authors | Elliott, JE; Kennedy, SW; Jeffrey, D; Shutt, L |
| Journal | Comparative Biochemistry and Physiology - Part C: Comparative Pharmacology and Toxicology |
| Volume | 99 |
| Issue | 1-2 |
| Page Numbers | 141-145 |
| Abstract | 1. In order to study the effects of polychlorinated biphenyls (PCBs) on American kestrels (Falco sparverius), groups of 6 female birds were fed toxic equivalent doses, estimated from rat studies, of either 2,3,3'4,4'-PCB (3 mg/kg/day) or 3,3',4,4',5-PCB (0.05 mg/kg/day) and a comparable dose of 2,2',4,4',5,5'-HxCB (4 mg/kg/day) for 4 weeks. <br>2. Livers were assayed for ethoxyresorufin OMICRON-deethylase (EROD), aminopyrine N-demethylase (APND) and aldrin epoxidase (AE) activity and also analyzed for concentrations of porphyrins by HPLC; abdominal fat was analyzed for residues of PCB congeners by GC/ECD. <br>3. Chronic dosing with 3,3',4,4',5-PCB (congener 126) caused significant induction of hepatic EROD and AE; dosing with 2,3,3'4,4'-PCB (congener 105) caused significant hepatic APND induction; dosing with 2,2',4,4',5,5'-HxCB (congener 153) caused significant induction of APND and AE. <br>4. None of the congeners had a significant effect on mean liver weight or mean hepatic porphyrin levels. <br>5. The data indicate that the relative response of kestrels to dosing with PCB congeners is different from both quail and rats. |
| Doi | 10.1016/0742-8413(91)90090-G |
| Wosid | WOS:A1991FF83400026 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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