Polychlorinated biphenyl-induced decrease in liver vitamin-a in Japanese-quail and rats
Cecil, HC; Harris, SJ; Bitman, J; Fries, GF
HERO ID
2156654
Reference Type
Journal Article
Year
1973
Language
English
PMID
| HERO ID | 2156654 |
|---|---|
| In Press | No |
| Year | 1973 |
| Title | Polychlorinated biphenyl-induced decrease in liver vitamin-a in Japanese-quail and rats |
| Authors | Cecil, HC; Harris, SJ; Bitman, J; Fries, GF |
| Journal | Bulletin of Environmental Contamination and Toxicology |
| Volume | 9 |
| Issue | 3 |
| Page Numbers | 179-185 |
| Abstract | HAPAB Young Japanese quail and rats were fed a control diet or one containing 100 ppm of p,p'-DDT or Aroclor 1242. After two months the animals were killed and the livers excised and analyzed. Both Aroclor 1242 and p,p'-DDT increased liver weight and liver lipids in male and female rats. Feeding DDT or PCB reduced liver vitamin A concentration in both male and female rats. The reduction in concentration was greater than that attributable to the corresponding increase in liver size. Total liver vitamin A in treated male and female rats was approximately half that in controls. In male quail PCB and DDT increased liver weight and decreased liver vitamin A. No effects of the treatments could be seen in female quail due to the great variations in individual data, presumably because of mobilization of liver constituents in formation of egg yolk. When egg laying was suppressed by maintaining the female quail in the dark from the onset of maturity, PCB and p,p'-DDT increased liver weight. PCB decreased liver vitamin A concentration to one-half of the control level and the total liver vitamin A to two-thirds of the control level. Aroclor feeding to female quail in standard lighting depressed egg production but did not affect egg weight or eggshell thickness. |
| Doi | 10.1007/BF01685000 |
| Pmid | 4205611 |
| Wosid | WOS:A1973P233600010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Bull ISSN: |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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