Carcinogenicity in mice of some fatty acid methyl esters 1. skin application
Arffmann, E; Glavind, J
| HERO ID | 2143417 |
|---|---|
| Year | 1974 |
| Title | Carcinogenicity in mice of some fatty acid methyl esters 1. skin application |
| Authors | Arffmann, E; Glavind, J |
| City | Denmark |
| Volume | 82 |
| Page Numbers | 127-136 |
| Abstract | HEEP COPYRIGHT: BIOL ABS. Two O2-containing derivatives of unsaturated fatty acids, methyl 12-oxo-trans- 10-octade-cenoate and methyl hydroxyoctadecadienoate, both highly active in the newt test for carcinogenicity, were tested as complete carcinogens and as promoting agents by application to the skin of ST/a mice. Through observation for 2 yr the tumorigenic effect was recorded and compared with that of methyl oleate and adequate positive control substances: 7,12-dimethylbenz(alpha)anthracene and croton oil. Methyl oxoctadecenoate and hydroxyoctadecadienoate showed a significant potency to promote the induction of skin papillomas. The genesis of malignant skin tumors was promoted by methyl oleate and oxoctadecnoate and all 3 methyl esters had weak activity as complete carcinogens to the skin. As a systemic effect all esters promoted the induction of malignant lymphomas, most markedly methyl oxoctadecenoate. Even without preceding initiation this ester and methyl oleate had some activity in lymphoma induction. The various observations show that, when tested by these procedures, methyl oxoctadecenoate is the ester most active in the induction of tumors and the effect is essentially that of a promoter. The relation between molecular configuration and carcinogenicity of fatty acids is discussed. |
| Doi | 10.1111/j.1699-0463.1974.tb03834.x |
| Pmid | 4827342 |
| Report Number | HEEP/75/02224 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: ACTA PATHOL MICROBIOL SCAND SECT A PATHOL ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | Index Medicus |
| Relationship(s) |
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