Availability of epidemiologic data on humans exposed to animal carcinogens: 2. Chemical uses and production volume
Karstadt, M; Bobal, R
| HERO ID | 2136483 |
|---|---|
| In Press | No |
| Year | 1982 |
| Title | Availability of epidemiologic data on humans exposed to animal carcinogens: 2. Chemical uses and production volume |
| Authors | Karstadt, M; Bobal, R |
| Journal | Teratogenesis, Carcinogenesis, and Mutagenesis |
| Volume | 2 |
| Issue | 2 |
| Page Numbers | 151-168 |
| Abstract | HEEP COPYRIGHT: BIOL ABS. Further findings of a survey of manufacturers, processors and importers of chemicals determined by the International Agency for Research on Cancer (IARC) to be animal carcinogens, but whose carcinogenicity in humans was considered uncertain because of inadequate epidemiologic data, are reported. Epidemiologic studies were obtained from companies marketing or using any of the 75 IARC animal carcinogens in commerce in the USA. Eighteen of the 75 IARC animal carcinogens had volumes listed of \ 106 lb/yr, with 8 of the 13 chemicals for which studies had been completed or are in progress in this high volume category. The use category with the largest number of chemicals was drugs-19 of the 75 IARC animal carcinogens were in this category. None of the 13 chemicals included in epidemiologic studies was a drug. Seven of the 13 chemicals included in studies were used primarily as pesticides. Little information was obtained on dyes and dye intermediates, experimental carcinogens and drugs, all of which are produced in relatively low volumes; these categories represent 42 of the 75 IARC animal carcinogens. Low volumes and declining usage/production appear to be barriers to performance of epidemiologic studies. Information received suggests that sometimes the problem of low production volume may be avoided by studying users rather than production workers. Overall, few additional epidemiologic studies of the 75 IARC animal carcinogens are expected. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |