Consensus report for dinitrotoluene
HERO ID
2078362
Reference Type
Book/Book Chapter
Year
1992
Language
English
| HERO ID | 2078362 |
|---|---|
| Year | 1992 |
| Title | Consensus report for dinitrotoluene |
| Book Title | Scientific basis for Swedish occupational standards XII |
| Authoring Organization | Criteria Group for Occupational Standards (Sweden) |
| Editor | Lundberg, P |
| Publisher Text | National Institute of Occupational Health |
| City | Solna, Sweden |
| Page Numbers | 63-73 |
| Abstract | Dose-effect/dose-response relationships Most reports of the effects of dinitrotoluene on human subjects lack data on air concentrations. Toxic effects such as formation of methemoglobin, anemia etc. have been reported in persons occupationally exposed to air concentrations that were probably above 1 mg/m3. In a later follow-up, when the air concentration at the factory was considerably below 1 mg/m3, 13 percent of 714 examined workers had anemia and/or subjective symptoms. A mortality study showed an over-frequency of deaths due to circulatory diseases, but no over-frequency of mortality due to caner. In one study, but not in two others, lower sperm counts were noted in the exposed groups. The exposure level was 0.013 to 0.12 mg/m3 for industrial DNT, but there was also exposure to toluene diamine. In animal studies, exposure has usually been via peroral administration. With regard to industrial DNT, the following can be noted: 3,5 mg/kg/day for 2 years caused hepatocellular carcinomas in male rats. 14 mg/kg/day for 2 years caused hepatocellular carcinomas in female rats. 35 mg/kg/day for 2 years also caused bile duct carcinomas in rats. 35 mg/kg/day for 1 years caused hepatocellular carcinomas in male rats. The effects noted in animal experiments with 2,4-DNT, the primary component of industrial DNT, are listed in Table I. With regard to 2,6-DNT, the following can be noted: Mice that received 25 mg/kg (intraperitoneal) 3 times/week for 8 weeks showed no increase in lung adenomas. A positive response was obtained with a dose of 37.5 mg/kg in an initiation-promotion system (carbon tetrachloride was one of the promotors used). Male rats that received 7 or 14 mg/kg/day in food for a year developed hepatocellular carcinomas. Conclusions The small amount of existing data on human exposure indicate that the critical effect of exposure to dinitroluene is its effect on the circulatory system. In animal studies, both industrial dinitrotoluene and 2,6-DNT have been shown to have both initiative and promotive qualities, while 2,4-DNT seems to work primarily as a promotor. Effects on gonads have also been observed in animal studies. |
| Is Certified Translation | No |
| Dupe Override | No |
| Series | Arbete och Hälsa, 1992:6 |
| Isbn | 9789170451584 |
| Is Public | Yes |
| Language Text | English |
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