A study on the inhibitory effects of several chemicals on the production of nitrogen oxide in alveolar macrophage induced by asbestos
Fan, JINGGUANG; Wang, QIEN; Wu, WEIDONG; Et, AL
| HERO ID | 2069270 |
|---|---|
| In Press | No |
| Year | 1997 |
| Title | A study on the inhibitory effects of several chemicals on the production of nitrogen oxide in alveolar macrophage induced by asbestos |
| Authors | Fan, JINGGUANG; Wang, QIEN; Wu, WEIDONG; Et, AL |
| Journal | Zhonghua Yufang Yixue Zazhi / Chinese Journal of Preventive Medicine |
| Volume | 31 |
| Issue | 1 |
| Page Numbers | 31-33 |
| Abstract | BIOSIS COPYRIGHT: BIOL ABS. Induction of chrysotile produced in Mang ai to the production of nitrogen oxide (NO) and effects of mixed rare earths (MRE), sodium selenite (SS) and aluminium citrate on the production of NO in alveolar macrophage (AM) induced by asbestos fiber were observed by in vitro cell culture technique and determination of nitrite ion content in the culture medium. Results showed that chrysotile fiber could increase nitrite ion content in the culture medium, with an obvious dose-dependent relationship. MRE, selenite, and aluminium citrate all could inhibit the production of NO in AM induced by asbestos, and its inhibitory effects increased with the concentration of the above-mentioned chemicals. It suggests antagonism of MRE and selenite to pathogenicity of asbestos may be used in practice. |
| Pmid | 9812634 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | Chinese |
| Keyword | Aluminum Compounds; Metals, Rare Earth; Mineral Fibers; Asbestos; 1332-21-4; Nitric Oxide; 31C4KY9ESH; Sodium Selenite; HIW548RQ3W; Index Medicus; Mineral Fibers -- adverse effects; Animals; Guinea Pigs; Aluminum Compounds -- pharmacology; Asbestos -- adverse effects; Sodium Selenite -- pharmacology; Metals, Rare Earth -- pharmacology; Macrophages, Alveolar -- metabolism; Nitric Oxide -- biosynthesis |