Risk of breast cancer and organochlorine exposure
Wolff, MS; Zeleniuch-Jacquotte, A; Dubin, N; Toniolo, P
HERO ID
202603
Reference Type
Journal Article
Year
2000
Language
English
PMID
| HERO ID | 202603 |
|---|---|
| In Press | No |
| Year | 2000 |
| Title | Risk of breast cancer and organochlorine exposure |
| Authors | Wolff, MS; Zeleniuch-Jacquotte, A; Dubin, N; Toniolo, P |
| Journal | Cancer Epidemiology Biomarkers and Prevention |
| Volume | 9 |
| Issue | 3 |
| Page Numbers | 271-277 |
| Abstract | A prospective investigation of breast cancer and organochlorine (OC) exposures was undertaken in the New York University Women's Health Study. Cases (n = 148) and individually matched controls (n = 295) were identified among women whose blood had been obtained 6 months or more prior to breast cancer diagnosis. In addition, among 84 cases and 196 controls, two or more consecutive annual blood samples were available to estimate half-lives of 1,1-dichloro-2,2-bis(p-chlorophenyl) ethene (DDE) and polychlorinated biphenyls (PCBs). Cases and controls had similar levels of DDE (geometric mean, 6.95 versus 7.27 ng/ml; lipid-adjusted geometric mean, 977 versus 1100 ng/g) and PCBs (5.04 versus 4.97 ng/ml; lipid-adjusted geometric mean, 683 versus 663 ng/g). These differences remained nonsignificant when estrogen receptor status of tumors was considered. DDE and PCB half-lives did not differ in case versus control patients. In control patients, DDE and PCB half-lives were strongly correlated (r(s) = 0.71), and the half-life of DDE (but not that of PCB) was inversely correlated with body mass index (BMI), yet the blood serum levels of PCB (but not those of DDE) were correlated with BMI. We conclude that there is no evidence for an association of breast cancer risk with DDE or PCB levels in blood (based on samples collected during the period 1987-1992) nor with their elimination half-lives. However, changes in DDE and PCBs over time are influenced by metabolism, BMI, and current OC exposures, and each may affect interpretation of OC levels in risk assessment models. |
| Pmid | 10750665 |
| Wosid | WOS:000085983500005 |
| Url | http://cebp.aacrjournals.org/content/9/3/271.abstract |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | N1-MarAN-10750665N1-Wolff, M SZeleniuch-Jacquotte, ADubin, NToniolo, PCA16087/CA/NCI NIH HHS/United StatesCA34588/CA/NCI NIH HHS/United StatesES06489/ES/NIEHS NIH HHS/United StatesResearch Support, U.S. Gov't, P.H.S.United statesCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyCancer Epidemiol Biomarkers Prev. 2000 Mar;9(3):271-7.N1-engAD-Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.ID-689 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Adult; Aged; Breast Neoplasms/epidemiology/*etiology; Case-Control Studies; Dichlorodiphenyl Dichloroethylene/*adverse effects/blood; Environmental Exposure; Female; Humans; Insecticides/*adverse effects/blood; Middle Aged; Polychlorinated Biphenyls/*adverse effects/blood; Prospective Studies; Risk Assessment |
| Is Qa | No |