Toxicity of selected symmetrical hexachlorobiphenyl isomers in the mouse
Biocca, M; Gupta, BN; Chae, K; Mckinney, JD; Moore, JA
HERO ID
201793
Reference Type
Journal Article
Year
1981
Language
English
PMID
| HERO ID | 201793 |
|---|---|
| In Press | No |
| Year | 1981 |
| Title | Toxicity of selected symmetrical hexachlorobiphenyl isomers in the mouse |
| Authors | Biocca, M; Gupta, BN; Chae, K; Mckinney, JD; Moore, JA |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 58 |
| Issue | 3 |
| Page Numbers | 461-474 |
| Abstract | Five-week-old male mice were given: 0.3, 1, 3, 10, 30, 100, or 300 ppm of 3,4,5,3?,4?,5?-hexachlorobiphenyl (HCB); 10, 30, 100 or 300 ppm of 2,4,5,2?,4?,5?-HCB, 2,3,6,2?,3?,6?-HCB, or 2,4,6,2?,4?,6?-HCB in feed daily for 28 days. HCB residue levels were determined in adipose tissue and liver. There were marked differences in dose response and severity of pathologic effects among the isomers. 3,4,5,3?,4?,5?-HCB was the most toxic isomer causing mortality, and body and organ weight effects at all dose levels, and was the only isomer which produced excess porphyrin accumulation. It was also the most concentrated isomer in fat and liver. 3,4,5,3?,4?,5?-HCB caused subcutaneous edema, enlargement of liver with accentuated hepatic lobular markings, fatty infiltration, hepatocellular swelling and necrosis, and atrophy of the thymus. 2,4,6,2?,4?,6?-HCB and 2,4,5,2?,4?,5?-HCB caused the same lesions but to a lesser degree. Slight cardiomyopathy was observed with 2,4,6,2?,4?,6?-HCB. The decreasing order of overall toxicity was 3,4,5-HCB >> 2,4,6-HCB > 2,4,5-HCB > 2,3,6-HCB. |
| Doi | 10.1016/0041-008X(81)90099-5 |
| Pmid | 6787738 |
| Wosid | WOS:A1981LT62500014 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | N1-MayAN-6787738N1-Biocca, MGupta, B NChae, KMcKinney, J DMoore, J AComparative StudyUnited statesToxicology and applied pharmacologyToxicol Appl Pharmacol. 1981 May;58(3):461-74.N1-engID-136 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Animals; Lethal Dose 50; Liver/drug effects/pathology; Male; Mice; Mice, Inbred C57BL; Organ Size/drug effects; Polychlorinated Biphenyls/*toxicity; Structure-Activity Relationship |
| Is Qa | No |