Developmental toxicity of thiophenol (THIO) in rats and rabbits
George, JD; Price, CJ; Navarro, HA; Marr, MC; Myers, CB; Hunter ES Schwetz, BA; Shelby, MD
HERO ID
201659
Reference Type
Journal Article
Subtype
Abstract
Year
1995
| HERO ID | 201659 |
|---|---|
| Material Type | Abstract |
| Year | 1995 |
| Title | Developmental toxicity of thiophenol (THIO) in rats and rabbits |
| Authors | George, JD; Price, CJ; Navarro, HA; Marr, MC; Myers, CB; Hunter ES Schwetz, BA; Shelby, MD |
| Journal | Toxicologist |
| Volume | 15 |
| Issue | 1 |
| Page Numbers | 160 |
| Abstract | THIO, used in the production of pesticides, polymers, and pharmaceuticals, and as a food additive, was tested for developmental toxicity in Sprague-Dawley rats (25/group) and New Zealand White rabbits (15-26/group). THIO was given po in corn oil to rats (0, 20, 35, or 50 mg/kg/day; gestational days (gd) 6-15) or rabbits (0, 10, 30 or 40 mg/kg/day; gd 6-19). Maternal body wt., food and water consumption (rats) were recorded. On gd 20 (rats) or 30 (rabbits), maternal organs and fetuses were weighed, and fetuses were examined for malformations (external, visceral, and skeletal). In rats, maternal body wt. change and food consumption were depressed in all THIO-treated groups on gd. 6-9. Gravid uterine wt. was decreased, and relative maternal liver wt. was increased at 50 mg/kg/day; kidney wt. was unaffected. Increased postimplantation loss and incidence of external malformations, and decreased live litter size were observed at 50 mg/kg/day. Female fetal body wt. was decreased at 35 mg/kg/day. In rabbits, maternal food intake tended to be lower, and body wt. change was decreased at 30 and 40 mg/kg/day on gd 12-15. Gravid uterine wt., liver and kidney wt. were unaffected. Postimplantation loss, litter size, average fetal body wt. and morphological development were unaffected. In summary, for rats, 20 mg/kg/day THIO was the low observed adverse effect level (LOAEL) for maternal toxicity, based on transient decreases in maternal wt. gain and food intake. A maternal no observed adverse effect level (NOAEL) was not determined. The developmental NOAEL in rats was 20 mg/kg/day; clear evidence of developmental toxicity was seen at greater than or equal to 35 mg/kg/day. In rabbits, the maternal NOAEL was 10 mg/kg/day. Maternal toxic effects at greater than or equal to 30 mg/kg/day were minor. The developmental NOAEL was greater than or equal to 40 mg/kg/day. |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Name | Society of Toxicology Annual Meeting |
| Is Public | Yes |
| Is Qa | No |