The activities of 2,2',5,5'-tetrachlorobiphenyl, its 3,4-oxide metabolite, and 2,2',4,4'-tetrachlorobiphenyl in tumor induction and promotion assays
Preston, BD; Miller, EC; Miller, JA
HERO ID
201482
Reference Type
Journal Article
Year
1985
Language
English
PMID
| HERO ID | 201482 |
|---|---|
| In Press | No |
| Year | 1985 |
| Title | The activities of 2,2',5,5'-tetrachlorobiphenyl, its 3,4-oxide metabolite, and 2,2',4,4'-tetrachlorobiphenyl in tumor induction and promotion assays |
| Authors | Preston, BD; Miller, EC; Miller, JA |
| Journal | Carcinogenesis |
| Volume | 6 |
| Issue | 3 |
| Page Numbers | 451-453 |
| Abstract | Sensitive assays for the induction of lung adenomas in A/J mice or skin papillomas in SENCAR mice failed to show activity for either 2,2',5,5'-tetrachlorobiphenyl or 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide. Injections of the 3,4-oxide into preweanling A/J mice caused considerable mortality, whereas the parent hydrocarbon did not. Both 2,2',5,5'- and 2,2',4,4'-tetrachlorobiphenyl showed promoting activity for hepatic gamma-glutamyl transpeptidase-positive foci initiated in rat liver by treatment with diethylnitrosamine. The promoting activity of 2,2',4,4'-tetrachlorobiphenyl was approximately 10-fold greater than that of the 2,2',5,5'-isomer. |
| Doi | 10.1093/carcin/6.3.451 |
| Pmid | 2858273 |
| Wosid | WOS:A1985AED2600021 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | N1-MarAN-2858273N1-Preston, B DMiller, E CMiller, J A5-T-32-ES07015/ES/NIEHS NIH HHS/United StatesCA-07175/CA/NCI NIH HHS/United StatesCA-22484/CA/NCI NIH HHS/United StatesResearch Support, U.S. Gov't, P.H.S.United statesCarcinogenesisCarcinogenesis. 1985 Mar;6(3):451-3.N1-engID-511Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022389718&doi=10.1093%2fcarcin%2f6.3.451&partnerID=40&md5=258153be8621d615c4e0deb1d00b8375 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Adenoma/chemically induced; Animals; *Carcinogens; Female; Liver Neoplasms, Experimental/chemically induced; Lung Neoplasms/chemically induced; Mice; Mice, Inbred Strains; Neoplasms, Experimental/*chemically induced; Papilloma/chemically induced; Polychlorinated Biphenyls/*toxicity; Rats; Skin Neoplasms/chemically induced; gamma-Glutamyltransferase/analysis |
| Is Qa | No |