Electro-Thermal Vaporization Direct Analysis in Real Time-Mass Spectrometry (DART-ETV-MS) for Rapid Water Contaminant Analysis during Space Missions
Dwivedi, P; Gazda, DB; Keelor, JD; Limero, TF; Wallace, WT; Macatangay, AV; Fernandez, FM
| HERO ID | 1998352 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Electro-Thermal Vaporization Direct Analysis in Real Time-Mass Spectrometry (DART-ETV-MS) for Rapid Water Contaminant Analysis during Space Missions |
| Authors | Dwivedi, P; Gazda, DB; Keelor, JD; Limero, TF; Wallace, WT; Macatangay, AV; Fernandez, FM |
| Journal | Analytical Chemistry |
| Volume | 85 |
| Issue | 20 |
| Page Numbers | 9898-9906 |
| Abstract | The development of a direct analysis in real time-mass spectrometry (DART-MS) method and first prototype vaporizer for the detection of low molecular weight (~30-100 Da) contaminants representative of those detected in water samples from the International Space Station is reported. A temperature-programmable, electro-thermal vaporizer (ETV) was designed, constructed, and evaluated as a sampling interface for DART-MS. The ETV facilitates analysis of water samples with minimum user intervention while maximizing analytical sensitivity and sample throughput. The integrated DART-ETV-MS methodology was evaluated in both positive and negative ion modes to 1) determine experiment conditions suitable for coupling DART with ETV as a sample inlet and ionization platform for time-of-flight MS, 2) to identify analyte response ions, 3) to determine the detection limit and dynamic range for target analyte measurement, and 4) to determine the reproducibility of measurements made with the method when using manual sample introduction into the vaporizer. Nitrogen was used as the DART working gas and the target analytes chosen for the study were ethyl acetate, acetone, acetaldehyde, ethanol, ethylene glycol, dimethylsilanediol, formaldehyde, isopropanol, methanol, methylethyl ketone, methylsulfone, propylene glycol, and trimethylsilanol. |
| Doi | 10.1021/ac402365k |
| Pmid | 24050110 |
| Wosid | WOS:000326126600067 |
| Url | https://search.proquest.com/scholarly-journals/electro-thermal-vaporization-direct-analysis-real/docview/2000312359/se-2?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | article; acetaldehyde; acetone; detection limit; ethanol; ethyl acetate; ethylene glycol; formaldehyde; ionization; isopropyl alcohol; mass spectrometry; methanol; molecular weight; nitrogen; propylene glycol; volatilization; water analysis |