Branchial versus intestinal silver toxicity and uptake in the marine teleost Parophrys vetulus
Grosell, M; Wood, C
HERO ID
199806
Reference Type
Journal Article
Year
2001
Language
English
PMID
| HERO ID | 199806 |
|---|---|
| In Press | No |
| Year | 2001 |
| Title | Branchial versus intestinal silver toxicity and uptake in the marine teleost Parophrys vetulus |
| Authors | Grosell, M; Wood, C |
| Journal | Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology |
| Volume | 171 |
| Issue | 7 |
| Page Numbers | 585-594 |
| Abstract | Exposure to elevated waterborne silver as AgNO3 (4.07 µM=448 µg l-1) in seawater resulted in osmoregulatory disturbance in the lemon sole (Parophrys vetulus). The main effects were increased plasma Na+ and Cl- concentrations which translated into increased plasma osmolality. Plasma Mg2+ levels were also slightly increased after 96 h exposure. Using radio-isotopic flux measurements, a 50% reduction in branchial unidirectional Na+ extrusion was observed after 48 h silver exposure. By applying an intestinal perfusion approach, we were able to separate and thus quantify the intestinal contribution to the observed silver-induced physiological disturbance and internal silver accumulation. This analysis revealed that the intestinal contribution to silver-induced ionoregulatory toxicity was as high as 50-60%. In marked contrast, internal silver accumulation (in liver and kidney) was found to be derived exclusively from uptake across the gills. Drinking of silver-contaminated seawater resulted in substantial silver accumulation in the intestinal tissue (but apparently not silver uptake across the intestine), which probably explains the intestinal contribution to silver-induced physiological disturbance. |
| Doi | 10.1007/s003600100209 |
| Pmid | 11686617 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | N1-Branchial versus intestinal silver toxicity and uptake in the marine teleost Parophrys vetulusID-13 |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |