Mechanistic aspects--the dioxin (aryl hydrocarbon) receptor.
Poellinger, L
HERO ID
199165
Reference Type
Journal Article
Subtype
Review
Year
2000
Language
English
PMID
| HERO ID | 199165 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2000 |
| Title | Mechanistic aspects--the dioxin (aryl hydrocarbon) receptor. |
| Authors | Poellinger, L |
| Journal | Food Additives and Contaminants |
| Volume | 17 |
| Issue | 4 |
| Page Numbers | 261-266 |
| Abstract | The Ah receptor mediates the toxicological responses of 2,3,7,8-TCDD and related compounds. Receptor-deficient animals were shown to be resistant to the toxic effects of dioxin, although there is also evidence for the existence of a receptor-independent pathway for dioxin-induced toxicity. In the cytosol the receptor is present in a non-activated ligand binding conformation. Association with Arnt in the nucleus turns the receptor complex into a ligand activated form. The physiological role of the receptor is not yet understood; however, the conservation of the receptor in a wide range of animal species (including humans) suggests a fundamental role in cellular physiology. |
| Doi | 10.1080/026520300283333 |
| Pmid | 10912240 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Ah receptor; ligand binding; molecular targets;, physiological function, receptor conformation, signal transduction |
| Is Qa | No |