Gaseous formaldehyde-induced DNA-protein crosslinks in liver, kidney and testicle of Kunming mice
Peng, G; Yang, X; Zhao, W; Sun, J; Cao, Y; Xu, Q; Yuan, J; Ding, S
HERO ID
1983107
Reference Type
Journal Article
Year
2006
Language
English
| HERO ID | 1983107 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | Gaseous formaldehyde-induced DNA-protein crosslinks in liver, kidney and testicle of Kunming mice |
| Authors | Peng, G; Yang, X; Zhao, W; Sun, J; Cao, Y; Xu, Q; Yuan, J; Ding, S |
| Journal | Life Science Journal |
| Volume | 3 |
| Issue | 3 |
| Page Numbers | 82-87 |
| Abstract | To explore the effect of distant-site toxicity, this study detected the amount of DNA-protein crosslinks (DPC) with KCI-SDS assay in liver, testicle, and kidney of the purebred Kunming mice treated with gaseous formaldehyde (FA). The results showed that gaseous FA couldn't cause DPC or could cause few DPC at the lower concentration (0.5 mg/m3), while could cause significant DPC at higher concentrations (1.0 mg/m3 and 3.0 mg/m3)( P < 0.01 ). The results suggested that FA could induce DPC in the distant organs (liver, testicle and kidney) of mice at relatively high concentrations, which indicated that FA might induce distant-site toxicity. |
| Url | http://www.sciencepub.net/life/life0303/life-0303-14.pdf |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | formaldehyde; distant-site toxicity; DNA-protein crosslinks; KCI-SDS assay |
| Is Peer Review | Yes |