Nasal cavity neoplasia in F344/N rats and (C57BL/6 x C3H)F1 mice inhaling propylene oxide for up to two years
Renne, RA; Giddens, WE; Boorman, GA; Kovatch, R; Haseman, JE; Clarke, WJ
HERO ID
1981951
Reference Type
Journal Article
Year
1986
Language
English
PMID
| HERO ID | 1981951 |
|---|---|
| In Press | No |
| Year | 1986 |
| Title | Nasal cavity neoplasia in F344/N rats and (C57BL/6 x C3H)F1 mice inhaling propylene oxide for up to two years |
| Authors | Renne, RA; Giddens, WE; Boorman, GA; Kovatch, R; Haseman, JE; Clarke, WJ |
| Journal | Journal of the National Cancer Institute |
| Volume | 77 |
| Issue | 2 |
| Page Numbers | 573-582 |
| Abstract | Propylene oxide (CAS: 75-56-9) was studied for potential carcinogenicity and chronic toxicity by inhalation in F344/N rats and (C57BL/6 × C3H)F1 mice. Groups of 50 animals of each sex were exposed to 0, 200, or 400 ppm propylene oxide for 6 hours/day, 5 days/week, for up to 103 weeks. Survival decreased in mice exposed to propylene oxide; the decrease was significant (P < .005) in mice exposed to 400 ppm. Survival of exposed rats was comparable to that of controls. Mean body weight of rats and mice exposed to 400 ppm propylene oxide decreased, when compared to that of controls, during the 2d year of exposure. Exposure to propylene oxide for up to 2 years induced inflammatory and proliferative responses in nasal cavity of both species. There was clear evidence of carcinogenicity in mice exposed to 400 ppm propylene oxide; 10 of 50 males and 5 of 50 females had hemangiomas or hemangiosarcomas of the nasal submucosa. Papillary adenomas involving the nasal respiratory epithelium and underlying submucosal glands were observed in 3 female rats and 2 male rats exposed to 400 ppm propylene oxide. |
| Doi | 10.1093/jnci/77.2.573 |
| Pmid | 3461216 |
| Wosid | WOS:A1986D493900034 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
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