Molecular Regulaion of BACE1 and Its Function at The Early Onset of Alzheimer's Disease
Wang Tan; Sun Xiu-Lian
| HERO ID | 1981909 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Molecular Regulaion of BACE1 and Its Function at The Early Onset of Alzheimer's Disease |
| Authors | Wang Tan; Sun Xiu-Lian |
| Journal | Shengwu Huaxue yu Shengwu Wuli Jinzhan / Progress in Biochemistry and Biophysics |
| Volume | 39 |
| Issue | 8 |
| Page Numbers | 709-714 |
| Abstract | A beta is the major components of amyloid plaque deposition in the brain, and is considered to be the initiating factor for the pathogenesis of Alzheimer's disease(AD). beta-amyloid precursor protein cleaving enzyme 1 (BACE1) is one of the important enzymes in the A beta production. The process of maturation and expression of BACE1 is regulated by a variety of factors. Some of the pathological changes of early onset of AD such as ischemia, hypoxia, inflammation and stress are considered to be BACE1 related. Many BACE1 and A beta related cytokines in the fluids may become potential biomarkers, which would provide ideas for early clinical diagnosis of AD. |
| Doi | 10.3724/SP.J.1206.2012.00217 |
| Wosid | WOS:000307851900005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | BACE1; A beta; Alzheimer's disease; biomarkers |