Increased dioxin-like compounds in the serum of women with peritoneal endometriosis and deep endometriotic (adenomyotic) nodules
Heilier, J-F; Nackers, F; Verougstraete, V; Tonglet, R; Lison, D; Donnez, J
HERO ID
197875
Reference Type
Journal Article
Year
2005
Language
English
PMID
| HERO ID | 197875 |
|---|---|
| In Press | No |
| Year | 2005 |
| Title | Increased dioxin-like compounds in the serum of women with peritoneal endometriosis and deep endometriotic (adenomyotic) nodules |
| Authors | Heilier, J-F; Nackers, F; Verougstraete, V; Tonglet, R; Lison, D; Donnez, J |
| Journal | Fertility and Sterility |
| Volume | 84 |
| Issue | 2 |
| Page Numbers | 305-312 |
| Abstract | Objective: To investigate the possible association between the body burden of dioxin-like compounds and endometriotic disease. Design: Case-control study. Setting: Gynecology ward in a university hospital. Patient(s): Seventy-one women with peritoneal endometriosis (n = 25) or deep endometriotic (adenomyotic) nodules (n = 25) and controls (n = 21). Intervention(s): Collection of 200 mL of blood (fasted) and face-to-face interview. Main Outcome Measure(s): Assessment of dioxin (PCDD), furan (PCDF), and dioxin-like PCB serum concentrations (picograms toxic equivalent [TEQ]/g lipids). Result(s): Age and body mass index were traced by linear multiple regression as determinants of total TEQ levels. After standardization for these variables (30 years and 22.5 kg/m2), the mean TEQ levels were 24.21 (controls), 30.62 (peritoneal endometriosis), and 37.60 (deep endometriotic [adenomyotic] nodules) pg TEQ/g lipids. Logistic regression analysis indicated a significantly increased risk of deep endometriotic (adenomyotic) nodules (odds ratio [OR], 3.3; 95% confidence interval [CI], 1.4–7.6) for an increment of 10 pg in total TEQ levels/g lipids. An increased risk was also found for peritoneal endometriosis (OR, 1.9; 95% CI, 0.9–3.8) for total TEQ levels and for dioxins alone (OR, 3.2; 95% CI, 1.0–9.9). Conclusion(s): The results provide the first epidemiological evidence of an association between increased PCDD/PCDF and PCB body burden and endometriosis. |
| Doi | 10.1016/j.fertnstert.2005.04.001 |
| Pmid | 16084869 |
| Wosid | WOS:000231231800009 |
| Url | http://linkinghub.elsevier.com/retrieve/pii/S0015028205008605 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | N1-Increased dioxin-like compounds in the serum of women with peritoneal endometriosis and deep endometriotic (adenomyotic) nodulesID-438 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Dioxins; PCDD; PCDF; PCBs; dioxin-like PCBs; endometriosis; deep endometriotic (adenomyotic) nodules |
| Is Qa | No |