Level of oxidative stress and damage in erythrocytes in apprentices indirectly exposed to lead
Ergurhan-Ilhan, I; Cadir, B; Koyuncu-Arslan, M; Arslan C; Gultepe, FM; Ozkan, G
HERO ID
197695
Reference Type
Journal Article
Year
2008
Language
English
PMID
| HERO ID | 197695 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Level of oxidative stress and damage in erythrocytes in apprentices indirectly exposed to lead |
| Authors | Ergurhan-Ilhan, I; Cadir, B; Koyuncu-Arslan, M; Arslan C; Gultepe, FM; Ozkan, G |
| Journal | Pediatrics International |
| Volume | 50 |
| Issue | 1 |
| Page Numbers | 45-50 |
| Abstract | Background: Oxidative stress (OS) may result in damage to critical macromolecules, and an association between lead (Pb) toxicity and OS is a matter of research. Therefore, the aim of the present study was to investigate the effect of Pb on the oxidative system in indirectly Pb-exposed male apprentices. Methods: Established parameters of Pb toxicity (aminolevulinic acid dehydratase index [ALAD index], zinc-protoporphyrin [ZPP]) as well as Pb-level in blood were determined in Pb-exposed apprentices (n > 25) and controls (n > 24). Enzymatic (glutathione peroxides [GPx], superoxide dismutase [SOD], catalase [CAT]) and non-enzymatic (α-tocopherol, β-carotene) indices of OS, and malondialdehyde (MDA) level were also determined. Results: There was a statistically significant increase in Pb level, ALAD index, ZPP concentration, GPx activity and MDA concentration in Pb-exposed apprentices when compared to controls. Although a statistically significant decrease in α-tocopherol and β-carotene levels was seen, SOD and CAT activities were unaltered in Pb-exposed apprentices. Pb level and duration of Pb exposure were correlated with each other, as well as various indices of OS and MDA concentration. Conclusions: Chronic indirect Pb exposure results in lipid peroxidation in erythrocytes of apprentices via OS, and duration of Pb exposure is a reliable marker of Pb toxicity. |
| Doi | 10.1111/j.1442-200X.2007.02442.x |
| Pmid | 18279204 |
| Wosid | WOS:000253121600009 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | erythrocytes; lead toxicity; lipid peroxidation; oxidative stress; workers |
| Is Qa | No |
| Relationship(s) |
|