Comparison of acute responses of mice livers to short-term exposure to nano-sized or micro-sized silver particles
Cha, K; Hong, H; Choi, Y; Lee, MJ; Park, JH; Chae, H; Ryu, G; Myung, H
HERO ID
195498
Reference Type
Journal Article
Year
2008
Language
English
PMID
| HERO ID | 195498 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | Comparison of acute responses of mice livers to short-term exposure to nano-sized or micro-sized silver particles |
| Authors | Cha, K; Hong, H; Choi, Y; Lee, MJ; Park, JH; Chae, H; Ryu, G; Myung, H |
| Journal | Biotechnology Letters |
| Volume | 30 |
| Issue | 11 |
| Page Numbers | 1893-1899 |
| Abstract | Mice were fed either 13 nm silver nanoparticles or 2–3.5 μm silver microparticles. The livers were then obtained after 3 days and subjected to a histopathological analysis. The nanoparticle-fed and microparticle-fed livers both exhibited lymphocyte infiltration in the histopathological analysis, suggesting the induction of inflammation. In vitro, a human hepatoma cell line (Huh-7) was treated with the same silver nanoparticles and microparticles. The mitochondrial activity and glutathione production were hardly affected. However, the DNA contents decreased 15% in the nanoparticle-treated cells and 10% in the microparticle-treated cell, suggesting a more potent induction of apoptosis by the nanoparticles. From a microarray analysis of the RNA from the livers of the nano- and micro-particle-fed mice, the expression of genes related to apoptosis and inflammation was found to be altered. These gene expression changes in the nanoparticle-treated livers lead to phenotypical changes, reflecting increased apoptosis and inflammation. The changes in the gene expression were confirmed by using a semi-quantitative RT-PCR. |
| Doi | 10.1007/s10529-008-9786-2 |
| Pmid | 18604478 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | N1-Comparison of acute responses of mice livers to short-term exposure to nano-sized or micro-sized silver particlesID-37 |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |
| Relationship(s) |
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