Phospholipase A2 activation and cell injury in isolated rat hepatocytes exposed to bromotrichloromethane, chloroform, and 1,1-dichloroethylene as compared to effects of carbon tetrachloride
Glende, EA, Jr; Recknagel, RO
HERO ID
195119
Reference Type
Journal Article
Year
1992
Language
English
PMID
| HERO ID | 195119 |
|---|---|
| In Press | No |
| Year | 1992 |
| Title | Phospholipase A2 activation and cell injury in isolated rat hepatocytes exposed to bromotrichloromethane, chloroform, and 1,1-dichloroethylene as compared to effects of carbon tetrachloride |
| Authors | Glende, EA, Jr; Recknagel, RO |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 113 |
| Issue | 1 |
| Page Numbers | 159-162 |
| Abstract | It was found that the four toxigenic agents, CCl4, CHCl3, CBrCl3, and 1,1-dichloroethylene (vinylidene chloride) all share the property of activating phospholipase A2 (PLA2) of isolated hepatocytes in suspension, as determined over a 60- or 120-min time period. In all cases, PLA2 activation, measured as the appearance of lysophosphatidylethanolamine, preceded the release of lactic dehydrogenase during incubation of the cells at 37 degrees C. It is concluded that for these halogenated hydrocarbons phospholipase A2 activation may be part of the chain of causality leading from initial bioactivation to ultimate cell death. |
| Doi | 10.1016/0041-008x(92)90021-j |
| Pmid | 1553751 |
| Wosid | WOS:A1992HK77900020 |
| Url | https://search.proquest.com/docview/72864219?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:A1992HK77900020 |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>Cytology and Cytochemistry-Animal</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-Proteins</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-Lipids</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Enzymes-Physiological Studies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Pathology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Metabolism-General Metabolism</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Metabolism-Lipids</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Digestive System-Pathology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxicology-General</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Muridae</kw> |
| Is Qa | No |
| Relationship(s) |
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