In vitro BALB/3T3 cell transformation assay of nonoxynol-9 and 1,4-dioxane
Sheu, CW; Moreland, FM; Lee, JK; Dunkel, VC
HERO ID
195078
Reference Type
Journal Article
Year
1988
Language
English
PMID
| HERO ID | 195078 |
|---|---|
| In Press | No |
| Year | 1988 |
| Title | In vitro BALB/3T3 cell transformation assay of nonoxynol-9 and 1,4-dioxane |
| Authors | Sheu, CW; Moreland, FM; Lee, JK; Dunkel, VC |
| Journal | Environmental and Molecular Mutagenesis |
| Volume | 11 |
| Issue | 1 |
| Page Numbers | 41-48 |
| Abstract | The spermicidal surfactant nonoxynol-9 (Igepal CO-630, GAF Corp.) and a potential impurity, 1,4-dioxane, were tested in the in vitro cell transformation assay using BALB/3T3 cells. Two treatment periods, 48 hr and 13 days, were used. Nonoxynol-9, tested at levels up to 10 micrograms/ml, did not induce transformation, whereas dioxane was very active in the induction of type III foci in the cultured BALB/3T3 cells. |
| Doi | 10.1002/em.2850110106 |
| Pmid | 2828043 |
| Wosid | WOS:A1988L737100004 |
| Url | https://www.proquest.com/scholarly-journals/vitro-balb-3t3-cell-transformation-assay/docview/78095995/se-2?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | N1-In vitro BALB/3T3 cell transformation assay of nonoxynol-9 and 1,4-dioxaneN1-2828043N1-D22N1-0893-6692Journal ArticleAD-Genetic Toxicology Branch, Food and Drug Administration, Washington, DC 20204.ID-7 |
| Is Public | Yes |
| Language Text | English |
| Keyword | cytotoxicity; methylcholanthrene; prolonged treatment |
| Is Qa | No |