Uptake and metabolism of toxicants in the respiratory tract
Dahl, AR; Gerde, P
| HERO ID | 194577 |
|---|---|
| In Press | No |
| Year | 1994 |
| Title | Uptake and metabolism of toxicants in the respiratory tract |
| Authors | Dahl, AR; Gerde, P |
| Journal | Environmental Health Perspectives |
| Volume | 102 |
| Issue | SUPPL. 11 |
| Page Numbers | 67-70 |
| Abstract | The sites of uptake and retention of inhalants within the respiratory tract influence which tissues are susceptible to damage. Physical and chemical properties of inhalants, including size, water:air and oil:water partition coefficients, and reactivity or susceptibility to metabolism are the major factors that affect deposition and retention. The high metabolic capacity of the cells of the olfactory tissue and bronchiolar Clara cells contributes to their susceptibility to damage from both inhaled and bloodborne toxicants. The major enzymes that metabolize pesticides and many other potential toxicants are the cytochrome P450 and flavin-containing monooxygenases and the carboxylesterases. |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Authoring Organization: National Board of Labour Protection (Finland) |
| Is Public | Yes |
| Language Text | eng |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-225185</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Inhalation studies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Pulmonary system</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Nasal cavity</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Respiratory irritants</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Toxic effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Aldehydes</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>In vivo studies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Dosimetry</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Laboratory animals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biotransformation</kw> |
| Is Qa | No |