Exposure to air pollution near a steel plant and effects on cardiovascular physiology: A randomized crossover study
Liu, L; Kauri, LM; Mahmud, M; Weichenthal, S; Cakmak, S; Shutt, R; You, H; Thomson, E; Vincent, R; Kumarathasan, P; Broad, G; Dales, R
HERO ID
1935355
Reference Type
Journal Article
Year
2014
Language
English
PMID
| HERO ID | 1935355 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | Exposure to air pollution near a steel plant and effects on cardiovascular physiology: A randomized crossover study |
| Authors | Liu, L; Kauri, LM; Mahmud, M; Weichenthal, S; Cakmak, S; Shutt, R; You, H; Thomson, E; Vincent, R; Kumarathasan, P; Broad, G; Dales, R |
| Journal | International Journal of Hygiene and Environmental Health |
| Volume | 217 |
| Issue | 2-3 |
| Page Numbers | 279-286 |
| Abstract | <strong>BACKGROUND: </strong>Iron and steel industry is an important source of air pollution emissions. Few studies have investigated cardiovascular effects of air pollutants emitted from steel plants.<br /><br /><strong>OBJECTIVE: </strong>We examined the influence of outdoor air pollution in the vicinity of a steel plant on cardiovascular physiology in Sault Ste. Marie, Canada.<br /><br /><strong>METHODS: </strong>Sixty-one healthy, non-smoking subjects (females/males=33/28, median age 22 years) spent 5 consecutive 8-hour days outdoors in a residential area neighbouring a steel plant, or on a college campus approximately 5 kilometres away from the plant, and then crossed over to the other site with a 9-day washout. Mid day, subjects underwent daily 30-minute moderate intensity exercise. Blood pressure (BP) and pulse rate were determined daily and post exercise at both sites. Flow-mediated vasodilation (FMD) was determined at the site near the plant. Air pollution was monitored at both sites. Mixed-effects regressions were run for statistical associations, adjusting for weather variables.<br /><br /><strong>RESULTS: </strong>Concentrations of ultrafine particles, sulphur dioxide (SO2), nitrogen dioxide (NO2) and carbon monoxide (CO) were 50-100% higher at the site near the plant than at the college site, with minor differences in temperature, humidity, and concentrations of particulate matter ≤2.5μm in size (PM2.5) and ozone (O3). Resting pulse rate [mean (95% confidence interval)] was moderately higher near the steel plant [+1.53bpm (0.31, 2.78)] than at the college site, male subjects having the highest pulse rate elevation [+2.77bpm (0.78, 4.76)]. Resting systolic and diastolic BP and pulse pressure, and post-exercise BP and pulse rate were not significantly different between two sites. Interquartile range concentrations of SO2 (2.9ppb), NO2 (5.0ppb) and CO (0.2ppm) were associated with increased pulse rate [0.19bpm (-0.00, 0.38), 0.86bpm (0.03, 1.68), and 0.11bpm (0.00, 0.22), respectively], ultrafine particles (10,256count/cm(3)) associated with increased pulse pressure [0.85mmHg (0.23, 1.48)], and NO2 and CO inversely associated with FMD [-0.14% (-0.31, 0.02), -0.02% (-0.03, -0.00), respectively]. SO2 during exercise was associated with increased pulse rate [0.26bpm (0.01, 0.51)].<br /><br /><strong>CONCLUSION: </strong>Air quality in residential areas near steel plants may influence cardiovascular physiology. |
| Doi | 10.1016/j.ijheh.2013.06.007 |
| Pmid | 23911139 |
| Wosid | WOS:000331595500019 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Air pollution; Blood pressure; Flow-mediated vasodilation; Pulse rate; Iron and steel industry |
| Relationship(s) |
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