Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats
Takenaka, S; Karg, E; Roth, C; Schulz, H; Ziesenis, A; Heinzmann, U; Schramel, P; Heyder, J
HERO ID
19055
Reference Type
Journal Article
Year
2001
Language
English
PMID
| HERO ID | 19055 |
|---|---|
| In Press | No |
| Year | 2001 |
| Title | Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats |
| Authors | Takenaka, S; Karg, E; Roth, C; Schulz, H; Ziesenis, A; Heinzmann, U; Schramel, P; Heyder, J |
| Journal | Environmental Health Perspectives |
| Volume | 109 |
| Issue | Suppl. 4 |
| Page Numbers | 547-551 |
| Abstract | The cardiovascular system is currently considered a target for particulate matter, especially for ultrafine particles. In addition to autonomic or cytokine mediated effects, the direct interaction of inhaled materials with the target tissue must be examined to understand the underlying mechanisms. In the first approach, pulmonary and systemic distribution of inhaled ultrafine elemental silver (EAg) particles was investigated on the basis of morphology and inductively coupled plasma mass spectrometry (ICP-MS) analysis. Rats were exposed for 6 hr at a concentration of 133 Ág EAg m3 (3 * 106 cm3, 15 nm modal diameter) and were sacrificed on days 0, 1, 4, and 7. ICP-MS analysis showed that 1.7 Ág Ag was found in the lungs immediately after the end of exposure. Amounts of Ag in the lungs decreased rapidly with time, and by day 7 only 4% of the initial burden remained. In the blood, significant amounts of Ag were detected on day 0 and thereafter decreased rapidly. In the liver, kidney, spleen, brain, and heart, low concentrations of Ag were observed. Nasal cavities, especially the posterior portion, and lung-associated lymph nodes showed relatively high concentrations of Ag. For comparison, rats received by intratracheal instillation either 150 ÁL aqueous solution of 7 Ág silver nitrate (AgNO3) (4.4 Ág Ag) or 150 ÁL aqueous suspension of 50 Ág agglomerated ultrafine EAg particles. A portion of the agglomerates remained undissolved in the alveolar macrophages and in the septum for at least 7 days. In contrast, rapid clearance of instilled water-soluble AgNO3 from the lung was observed. These findings show that although instilled agglomerates of ultrafine EAg particles were retained in the lung, Ag was rapidly cleared from the lung after inhalation of ultrafine EAg particles, as well as after instillation of AgNO3, and entered systemic pathways. |
| Doi | 10.2307/3454667 |
| Pmid | 11544161 |
| Wosid | WOS:000170700500012 |
| Url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240579/?tool=pubmed |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB.Environ. Health Perspect. 109(suppl. 4): 547-551. |
| Is Public | Yes |
| Language Text | English |
| Keyword | distribution; ICP-MS; inhalation; instillation; morphology; silver; ultrafine |
| Is Qa | No |