A rapid access to new coumarinyl chalcone and substituted chromeno[4,3-c]pyrazol-4(1H)-ones and their antibacterial and DPPH radical scavenging activities
Hamdi, N; Fischmeister, C; Carmen Puerta, M; Valerga, P
| HERO ID | 1866397 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | A rapid access to new coumarinyl chalcone and substituted chromeno[4,3-c]pyrazol-4(1H)-ones and their antibacterial and DPPH radical scavenging activities |
| Authors | Hamdi, N; Fischmeister, C; Carmen Puerta, M; Valerga, P |
| Journal | Medicinal Chemistry Research |
| Volume | 20 |
| Issue | 4 |
| Page Numbers | 522-530 |
| Abstract | A series of new coumarin derivatives 4 containing a chalcone moiety were synthesized by condensation of 3-acetyl-4-hydroxycoumarin 1 with aryl or heteroaryl aldehydes 2 in the presence of piperidine in chloroform. The interaction of 3-formyl-4-chloro-coumarin 3 with nitrogen compound nucleophiles are described and lead to the corresponding substituted chromen[4,3-c] pyrazol-4-ones 5. The structures of the obtained compounds were established on the basis of IR|1D|2D NMR, while crystal structure of 3-acetyl-4-hydroxy coumarin 1 was determined using X-ray diffraction and further were evaluated for possible antibacterial and antioxidant activities. The coumarinic chalcone 4d has been found to be the most active (IC(50) = 2.07 mu M) in this study. |
| Doi | 10.1007/s00044-010-9326-1 |
| Wosid | WOS:000289001900015 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Coumarin derivatives; Crystal structure; Chalcone |