N-myc downstream regulated gene 1 (NDRG1)/Cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma
Akiba, Jun; Ogasawara, S; Kawahara, A; Nishida, N; Sanada, S; Moriya, F; Kuwano, M; Nakashima, O; Yano, H
HERO ID
1840267
Reference Type
Journal Article
Year
2008
Language
English
PMID
| HERO ID | 1840267 |
|---|---|
| In Press | No |
| Year | 2008 |
| Title | N-myc downstream regulated gene 1 (NDRG1)/Cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma |
| Authors | Akiba, Jun; Ogasawara, S; Kawahara, A; Nishida, N; Sanada, S; Moriya, F; Kuwano, M; Nakashima, O; Yano, H |
| Journal | Oncology Reports |
| Volume | 20 |
| Issue | 6 |
| Page Numbers | 1329-1335 |
| Abstract | N-myc downstream regulated gene 1 (NDRG1)/Cap43 is a 43 kDa protein that is widely distributed in the body. Its expression is regulated by nickel, cobalt, hypoxic condition and others; it is reported to be weaker in tumors than normal tissues; and NDRG1/Cap43 is considered to act suppressively to tumor metastasis. This current study immunohistochemically examined NDRG1/Cap43 expression in hepatocellular carcinoma (HCC), and analyzed its relationship to clinicopathologic factors and prognosis. The samples were 105 surgically resected HCC tissue blocks, i.e., 18 well-differentiated HCC, 61 moderately differentiated HCC, 10 poorly differentiated HCC, 9 'nodule-in-nodule' type HCC, and 7 sarcomatous HCC. In all cases, NDRG1/Cap43 was not expressed in normal liver cells. Strong expression was found in 65 of the 105 cases (62%), i.e., in 11.1% of well-differentiated HCC, 72.1% of moderately differentiated HCC, 80.0% of poorly differentiated HCC, and 71.4% of sarcomatous HCC. In the 'nodule-in-nodule' type, its expression was found in 55.6% of their well-differentiated component, and this frequency was significantly higher than that in well-differentiated HCC (11.1%). In the cases showing strong NDRG1/Cap43 expression, frequency of portal vein invasion and of intrahepatic metastasis was significantly high. No clear relationship between the expression and prognosis was observed. NDRG1/Cap43 expression that was found in advanced HCC was thought to accelerate tumor invasion and metastasis. NDRG1/Cap43 could act as a useful biomarker of HCC. |
| Doi | 10.3892/or_00000148 |
| Pmid | 19020710 |
| Wosid | WOS:000261293300005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000261293300005 |
| Is Public | Yes |
| Language Text | English |
| Keyword | N-myc; Cap43; hepatocellular carcinoma |