Synthesis, structure, electrochemistry and spectral characterization of (D-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich Ascites Carcinoma in Swiss albino mice
Sathisha, MP; Budagumpi, S; Kulkarni, NV; Kurdekar, GS; Revankar, VK; Pai, KSR
| HERO ID | 1840182 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Synthesis, structure, electrochemistry and spectral characterization of (D-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich Ascites Carcinoma in Swiss albino mice |
| Authors | Sathisha, MP; Budagumpi, S; Kulkarni, NV; Kurdekar, GS; Revankar, VK; Pai, KSR |
| Journal | European Journal of Medicinal Chemistry |
| Volume | 45 |
| Issue | 1 |
| Page Numbers | 106-113 |
| Abstract | The novel glycosyl saccharide derivative, (D-glucopyranose)-4-phenylthiosemicarbazide (LH) and its complexes, with cobalt(II), nickel(II), copper(II) and zinc(II) were synthesized, characterised and tested for cytotoxic effects. The copper complex, [CuLCl] inhibited Ehrlich Ascites Carcinoma (EAC) induced cancer cell lines in Swiss albino mice at LC50=1.94 x 10(-8) (LC50=2.76 x 10(-8) for cisplatin) and so distinctly better than free ligand and other complexes. |
| Doi | 10.1016/j.ejmech.2009.09.031 |
| Pmid | 19854545 |
| Wosid | WOS:000274203000014 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000274203000014 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Transition metal complexes; Thiosemicarbazide; Antitumor activity; Cytotoxicity |