Differential effects of Co(III), Ni(II), and Ru(III) amine complexes on Sindbis virus
Knight, DA; Hickey, TE; Bongard, JE; Thach, DC; Yngard, R; Chang, EL
| HERO ID | 1840069 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Differential effects of Co(III), Ni(II), and Ru(III) amine complexes on Sindbis virus |
| Authors | Knight, DA; Hickey, TE; Bongard, JE; Thach, DC; Yngard, R; Chang, EL |
| Journal | Journal of Inorganic Biochemistry |
| Volume | 104 |
| Issue | 5 |
| Page Numbers | 592-598 |
| Abstract | Transition metal complexes [Co(cyclen)(NH(3))(2)](ClO(4))(3)H(2)O (cyclen=1,4,7,10-tetraazacyclododecane) (2), [Co(NH(3))(5)(OH(2))](CF(3)SO(3))(3) (3) [Ni(NH(3))(6)]Br(2) (4) and [Ru(NH(3))(6)]Cl(3) (5) were tested against Sindbis infected baby hamster kidney (BHK) cells and show differential effects from the previously reported anti-viral complex [Co(NH(3))(6)]Cl(3) (1). The macrocyclic complex 2 and labile aqua complex 3 show either no or little effect on the survival on Sindbis virus-infected cells as compared to that for 1, which show a monotonic increase in % BHK cell survival. Nickel and ruthenium ammine complexes 4 and 5 had a moderate influence of cell survival. While the results showed some anti-viral activity for some of the structural variations, it appears that 1, with its potential to be a broad-spectrum anti-viral compound, occupies a unique position in its ability to both significantly enhance cell survival and to decrease viral expression of infected cells. We also show that 1 also shows anti-viral activity against Adenovirus lending support to the broad-spectrum potential of this complex. |
| Doi | 10.1016/j.jinorgbio.2010.01.012 |
| Pmid | 20189656 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000276274700013 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Hexaamminecobalt(III) chloride; Anti-viral; Metal complexes; Broad-spectrum drug |