Further studies on incomplete carcinogenesis: triethylene melamine (T.E.M.), 1,2-benzanthracene and beta-propiolactone, as initiators of skin tumour formation in the mouse
Roe, FJ; Salaman, MH
HERO ID
1787125
Reference Type
Journal Article
Year
1955
Language
English
PMID
| HERO ID | 1787125 |
|---|---|
| In Press | No |
| Year | 1955 |
| Title | Further studies on incomplete carcinogenesis: triethylene melamine (T.E.M.), 1,2-benzanthracene and beta-propiolactone, as initiators of skin tumour formation in the mouse |
| Authors | Roe, FJ; Salaman, MH |
| Journal | British Journal of Cancer |
| Volume | 9 |
| Issue | 1 |
| Page Numbers | 177-203 |
| Abstract | 1. As a sequel to the demonstration that urethane applied to mouse skin followed by repeated applications of a promoting agent (croton oil) acts as an initiator of carcinogenesis, 29 substances, most of them related pharmacologically or chemically to urethane, have been screened for similar activity. 2. Of four antileukaemic agents tested, triethylene melamine (T.E.M.) was found to be an effective initiator of carcinogenesis but not carcinogenic, for mouse skin, in the doses tested; nitrogen mustard, Myleran, and aminopterin, in maximum sublethal doses, showed no initiating activity. 3. Of five substances exerting a specific effect on mitosis (in addition to those included in the category of anti-leukaemic agents), none showed initiating activity. 4. Of six narcotic agents tested none showed unequivocal evidence of initiating activity. 5. Of eight urethane derivatives and related compounds, ethyl N-methyl carbamate and ethyl N-phenyl carbamate showed weak initiating activity. In neither case was this as strong as that of a molecularly equivalent dose of urethane. (See Addendum II). 6. Four miscellaneous substances were tested. Of these 1,2-benzanthracene was found to be an effective initiator of carcinogenesis but not carcinogenic, in the doses used; and β-propiolactone was found to be an initiator of carcinogenesis. The latter is being tested for carcinogenicity at present. (See Addendum I.) 7. The use of the âtâ test of statistical significance for skew distributions, such as those encountered in these results, is discussed. As an alternative, a ranking test is proposed. 8. The histological appearance of the skin following one, or two, applications of the test substances is described. Of those with initiating activity triethylene melamine, ethyl N-methyl carbamate and ethyl N-phenyl carbamate gave rise to no recognisable changes in the skin. 1,2-Benzanthracene consistently produced a moderate epidermal hyperplasia. The response to β-propiolactone varied from slight to marked epidermal hyperplasia. 9. The results are discussed, and an attempt is made to correlate initiating activity with other properties. © 1955, The British Empire Cancer Campaign for Research. All rights reserved. |
| Doi | 10.1038/bjc.1955.14 |
| Pmid | 14378502 |
| Url | https://www.proquest.com/docview/81514652?accountid=171501&bdid=13857&_bd=DHJdLaBhY2AYGK%2BqR7PqVTB00aI%3D |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84965189531&doi=10.1038%2fbjc.1955.14&partnerID=40&md5=179cae33842557b828a914290ae8739d |
| Is Public | Yes |
| Language Text | English |
| Keyword | benz[a]anthracene; benz[a]anthracene derivative; carcinogen; propiolactone; propionic acid derivative; tretamine; animal; carcinogenesis; mouse; skin tumor; Animals; Benz(a)Anthracenes; Carcinogenesis; Carcinogens; Mice; Propiolactone; Propionates; Skin Neoplasms; Triethylenemelamine |