Inductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde
Furihata, C; Yamakoshi, A; Matsushima, T
HERO ID
1778011
Reference Type
Journal Article
Year
1988
Language
English
PMID
| HERO ID | 1778011 |
|---|---|
| In Press | No |
| Year | 1988 |
| Title | Inductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde |
| Authors | Furihata, C; Yamakoshi, A; Matsushima, T |
| Journal | Japanese Journal of Cancer Research |
| Volume | 79 |
| Issue | Gann |
| Page Numbers | 917-920 |
| Abstract | The induction of ornithine-decarboxylase (ODC) activity and DNA synthesis was studied in the glandular stomach mucosa of rats after gastric intubation of formaldehyde (50000) (FA). Male Fischer-rats were given doses of FA ranging from 11 to 110mg/kg body weight by gastric intubation between 8 and 10 in the morning following a restricted amount of food overnight. In a second experiment, they were given the FA at 6 pm. The maximum increase in ODC activity was a 100 fold increase noted after 16 hours. The maximum increase in DNA synthesis was a 49 fold increase after 16 hours in the pyloric mucosa of the stomach. Even doses lower than 75mg/kg, FA induced ODC activity and DNA synthesis in the pyloric mucosa in this study. All the glandular stomach carcinogens and tumor promoters examined have thus far been found to induce ODC activity and stimulate DNA synthesis in the glandular stomach mucosa. The results of this study indicate that inductions of ODC activity and DNA synthesis are useful markers of possible tumor promoting activity in the glandular stomach mucosa. The authors suggest the possibility that stomach tumor promoters can be predicted by this in-vivo short term assay. |
| Pmid | 3141327 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Jpn J Cancer Res (Gann) ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-173697</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Gastrointestinal system disorders</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Carcinogens</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Laboratory animals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Enzyme activity</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Nucleic acids</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Stomach disorders</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Stomach cancer</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Formaldehydes</kw> |