Lack of dominant lethality in mice following 1-bromopropane treatment
Chung, MK; Yu, WJ; Han, SS
HERO ID
1737869
Reference Type
Journal Article
Subtype
Abstract
Year
2006
Language
English
| HERO ID | 1737869 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2006 |
| Title | Lack of dominant lethality in mice following 1-bromopropane treatment |
| Authors | Chung, MK; Yu, WJ; Han, SS |
| Journal | Reproductive Toxicology |
| Volume | 22 |
| Issue | 2 |
| Abstract | 1-Bromopropane (1-BP) is widely used in spray adhesives and as a precision cleaner and degreaser. This study was conducted to investigate the potential of 1-BP to induce dominant lethality in mice. 1-BP was orally administered to males at 300 and 600 mg/kg for 10 days before mating. Cyclophosphamide was used as a positive control (PC), which was administered intraperitoneally to males at 40 mg/kg for 5 days. The vehicle control (VC) group received corn oil only. Thereafter males were mated with untreated females during six sequential mating periods of a weak each. Males were sacrificed at the end of mating and pregnant females on days 15 and #150;17 of gestation. Clinical signs, gross findings, mating index, gestation index, no. of corpora lutea and implantations, pre-implantation loss, live fetuses, resorptions, dead fetuses, post-implantation loss and dominant lethal mutation rate were examined. There were no treatment-related changes in clinical signs, gross findings, mating index, gestation index, no. of corpora lutea and implantations, pre-implantation loss, live fetuses, resorptions, dead fetuses, post-implantation loss at all 1-BP doses tested. In the PC group, there were no treatment-related changes in mating index, gestation index, no. of corpora lutea and dead fetuses. However, a decrease in no. of implantations and an increase in pre-implantation loss were observed in 1 and 2 weeks of mating, compared to those of the VC group. No treatment-related changes were observed in 3 and #150;6 weeks of mating. An increase in resorptions, fetal deaths and post-implantation loss, and a decrease in no. of live fetuses were observed in 1 and #150;3 weeks of mating of the PC group, compared to those of the VC group. However, no treatment-related changes were observed in 4 and #150;6 weeks of mating. An increase in dominant lethal mutation rate was observed in 1 and #150;3 weeks of mating of the PC group, but there was no difference in 1 and #150;6 weeks of mating of the 1-BP treatment groups. In conclusion, 1-BP did not induce dominant lethality in mice. These results are in good agreement with the report of Saito-Suzuki et al. [1] that no dominant lethality of 1-BP was observed in SD rats. |
| Url | http://www.sciencedirect.com/science/article/pii/S0890623806001201# |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Abano Terme, Italy |
| Conference Name | 34th Annual Conference of the European Teratology Society |
| Conference Date | September 3-6, 2006 |
| Comments | Authoring Organization: National Board of Labour Protection (Finland) |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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