[Effects of inorganic nitrates on thyroid gland activity and morphology in female rats]
Chaoui, AA; Zaki, A; Talibi, A; Chait, A; Derouiche, A; Aboussaouira, T; Benabdjlil, F; Himmi, T
| HERO ID | 1679002 |
|---|---|
| In Press | No |
| Year | 2004 |
| Title | [Effects of inorganic nitrates on thyroid gland activity and morphology in female rats] |
| Authors | Chaoui, AA; Zaki, A; Talibi, A; Chait, A; Derouiche, A; Aboussaouira, T; Benabdjlil, F; Himmi, T |
| Journal | Therapie |
| Volume | 59 |
| Issue | 4 |
| Page Numbers | 471-475 |
| Abstract | The present study was undertaken to determine the effects of intake of inorganic nitrates in drinking water on thyroid gland activity and morphology in female rats. During 5 months of treatment, nitrates 50, 150 and 500 mg/L induced a significant dose-dependent decrease in bodyweight gain, compared with the control rats. At the end of the experiment, nitrates 150 and 500 mg/L induced hypertrophy of the thyroid gland, accompanied by an increase in the size of the thyroid follicles and hyposecretion of thyroid hormones T3 (triiodothyronine) and T4 (tetraiodothyronine). We concluded that a high nitrate intake in water influenced thyroid gland activity and morphology and might be considered to be a goitrogenic factor. |
| Doi | 10.2515/therapie:2004079 |
| Pmid | 15559551 |
| Wosid | WOS:000224950600015 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | French |
| Keyword | nitrates; thyroid gland; thyroid hormones; goitre |
| Is Peer Review | Yes |
| Relationship(s) |
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