Simplex optimization of headspace factors for headspace gas chromatography determination of residual solvents in pharmaceutical products
Grodowska, K; Parczewski, A
HERO ID
1609680
Reference Type
Journal Article
Year
2013
Language
English
PMID
| HERO ID | 1609680 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Simplex optimization of headspace factors for headspace gas chromatography determination of residual solvents in pharmaceutical products |
| Authors | Grodowska, K; Parczewski, A |
| Journal | Acta Poloniae Pharmaceutica |
| Volume | 70 |
| Issue | 2 |
| Page Numbers | 181-189 |
| Abstract | The purpose of the present work was to find optimum conditions of headspace gas chromatography (HS-GC) determination of residual solvents which usually appear in pharmaceutical products. Two groups of solvents were taken into account in the present examination. Group I consisted of isopropanol, n-propanol, isobutanol, n-butanol and 1,4-dioxane and group II included cyclohexane, n-hexane and n-heptane. The members of the groups were selected in previous investigations in which experimental design and chemometric methods were applied. Four factors were taken into consideration in optimization which describe HS conditions: sample volume, equilibration time, equilibrium temperature and NaCl concentration in a sample. The relative GC peak area served as an optimization criterion which was considered separately for each analyte. Sequential variable size simplex optimization strategy was used and the progress of optimization was traced and visualized in various ways simultaneously. The optimum HS conditions appeared different for the groups of solvents tested, which proves that influence of experimental conditions (factors) depends on analyte properties. The optimization resulted in significant signal increase (from seven to fifteen times). |
| Pmid | 23614273 |
| Wosid | WOS:000316432100002 |
| Url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876721022&partnerID=40&md5=61d375d41c4b306df32456ecb190dca1 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000316432100002Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876721022&partnerID=40&md5=61d375d41c4b306df32456ecb190dca1 |
| Is Public | Yes |
| Language Text | English |
| Keyword | residual solvents; headspace-gas chromatography; optimization; simplex method |