Effect of bis(tributyltin)phthalate on the fetal development. II
Kawashima, K; Usami, M; Sakimura, M; Tanaka, S; Takanaka, A
HERO ID
1599658
Reference Type
Journal Article
Subtype
Abstract
Year
1993
Language
English
| HERO ID | 1599658 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1993 |
| Title | Effect of bis(tributyltin)phthalate on the fetal development. II |
| Authors | Kawashima, K; Usami, M; Sakimura, M; Tanaka, S; Takanaka, A |
| Journal | Teratology |
| Volume | 48 |
| Issue | 5 |
| Page Numbers | 528 |
| Abstract | Bis(tributyltin)phthalate (TBTP) dissolved in sesame oil was administered orally to pregnant rats (Crj:Wistar) via stomach tube at the daily dose of 30 mg/kg at different times of the fetal organogenesis, i.e. 6th to 8th day, 9th to 11th day, 12th to 14th day and 15th to 17th day, and the critical period on teratogenicity of TBTP was examined in the fetuses. Gross malformations, such ascleft palate and general edema were observed in 9th to 11th day (0.6%), 12th to 14th day (10.1%) and 15th to 17th day (0.6%) treated groups. The highest incidence of gross malformation was observed in the 12th to 14th day treated group. The incidence of internal anomalies increased in 6th to 8th day (25.8%), 9th to 11th day (35.5%), 12th to 14th day (54.7%) and 15th to 17th day (24.5%) treated groups. Highest incidence of internal organ malformation was observed in 12th to 14th day treated group. Various types of skeletal anomalies were observed in 6th to 8th day (48.8%), 9th to 11th day (77.5%), 12th to 14th day (74.0%) and 15th to 17th day (32.5%) treated groups. Highest incidence of skeletal anomalies was observed in 9th to 11th day treated group. It is concluded that the critical period in induction of gross and internal malformation by administration of TBTP exists between 12th and 14th day of gestation. However, critical period in skeletal anomaly exist between the 9th and 11th day. |
| Wosid | BCI:BCI199497109313 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Nagoya, Japan |
| Conference Name | Thirty‐third annual meeting of the Japanese Teratology Society |
| Conference Date | July 21-23, 1993 |
| Is Public | Yes |
| Language Text | English |