Teratogenicity of di-n-butylphthalate
Ema, M; Amano, H; Kawasaki, H
HERO ID
1599657
Reference Type
Journal Article
Year
1993
Language
English
| HERO ID | 1599657 |
|---|---|
| In Press | No |
| Year | 1993 |
| Title | Teratogenicity of di-n-butylphthalate |
| Authors | Ema, M; Amano, H; Kawasaki, H |
| Journal | Teratology |
| Volume | 48 |
| Issue | 5 |
| Page Numbers | 508-509 |
| Abstract | Di-n-butyl phthalate (DBP), a common plasticizer, was tested for developmental toxicity in Wistar rats. Pregnant rats were orally given DBP at a dose of 0.5, 0.63, 0.75 or 1.0 g/kg on days 7-15 of pregnancy (day 0 sperm positive). Maternal death and complete resorption of implanted embryos in all surviving dams were observed at 1.0 g/kg. Increased postimplantation loss and decreased fetal weight were found at doses of 0.63 and 0.75 g/kg. A significantly increased incidence of fetal malformations was detected at 0.75 g/kg. Cleft palate was predominantly observed. To evaluate the susceptible period for teratogenicity of DBP, pregnant rats were orally given DBP at a dose of 0.75, 1.0 or 1.5 g/kg on days 7-9, 10-12 or 13-15 of pregnancy. Postimplantation loss was 100% for each period of dosing at 1.5 g/kg. A significant increase in postimplantation loss was found in dams given DBP at doses of 0.75 and 1.0 g/kg regardless of the days of treatment. No evidence of teratogenicity was detected when DBP was given on days 10-12. Treatment on days 7-9 with DBP at doses of 0.75 and 1.0 g/kg caused a significant increase in incidences of skeletal malformations, such as deformity of vertebral column in cervical and thoracic regions and of ribs, but neither external nor internal malformations. Treatment on days 13-15 at 0.75 or 1.0 g/kg resulted in a significantly increased incidence of fetuses with external and skeletal malformations, such as cleft palate and fusion of sternebrae. The highest incidence of malformed fetuses occurred after treatment with DBP on days 13-15. It could be concluded that developing embryo has biphasic susceptibility to teratogenicity of DBP in rats. |
| Wosid | BCI:BCI199497109247 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Nagoya, Japan |
| Conference Name | Thirty-Third Annual Meeting of the Japanese Teratology Society |
| Conference Date | July 21-23, 1993 |
| Is Public | Yes |
| Language Text | English |