Influence of entero soluble formulations on the physiologic availability of active ingredients. 4. Influence of the enteric polymer dissolution pH on the in vivo absorption of aspirin from coated tablets
Delporte, JP; Jaminet, F
| HERO ID | 1599442 |
|---|---|
| In Press | No |
| Year | 1976 |
| Title | Influence of entero soluble formulations on the physiologic availability of active ingredients. 4. Influence of the enteric polymer dissolution pH on the in vivo absorption of aspirin from coated tablets |
| Authors | Delporte, JP; Jaminet, F |
| Journal | Journal de Pharmacie de Belgique |
| Volume | Pharm |
| Issue | REF 8 |
| Page Numbers | 263-276 |
| Abstract | IPA COPYRIGHT: ASHP The effects of the dissolution pH value of hydroxypropylmethylcellulose phthalate (pH 5), cellulose acetate phthalate (pH 6) and Eudragit (pH 7) on the intestinal absorption of enteric coated aspirin tablets were studied. No significant difference was observed between salicylate blood levels corresponding to tablets coated with either cellulose preparation, however, 2 of 6 volunteers receiving the Eudragit coated tablet did not absorb aspirin. These results show that enteric coating materials should not dissolve at a pH value higher than 6. Moreover, they confirm that disintegration tests of enteric products should be performed in simulated intestinal fluids at a pH value lower than 7. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
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