Postsynthetic modifications of iron-carboxylate nanoscale metal-organic frameworks for imaging and drug delivery
Taylor-Pashow, KM; Della Rocca, J; Xie, Z; Tran, S; Lin, W
HERO ID
1599055
Reference Type
Journal Article
Year
2009
Language
English
PMID
| HERO ID | 1599055 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Postsynthetic modifications of iron-carboxylate nanoscale metal-organic frameworks for imaging and drug delivery |
| Authors | Taylor-Pashow, KM; Della Rocca, J; Xie, Z; Tran, S; Lin, W |
| Journal | Journal of the American Chemical Society |
| Volume | 131 |
| Issue | 40 |
| Page Numbers | 14261-14263 |
| Abstract | Fe(III)-carboxylate nanoscale metal-organic frameworks (NMOFs) with the MIL-101 structure were synthesized using a solvothermal technique with microwave heating. The approximately 200 nm particles were characterized using a variety of methods, including SEM, PXRD, nitrogen adsorption measurements, TGA, and EDX. By replacing a percentage of the bridging ligand (terephthalic acid) with 2-amino terephthalic acid, amine groups were incorporated into the framework to provide sites for covalent attachment of biologically relevant cargoes while still maintaining the MIL-101 structure. In proof-of-concept experiments, an optical contrast agent (a BODIPY dye) and an ethoxysuccinato-cisplatin anticancer prodrug were successfully incorporated into the Fe(III)-carboxylate NMOFs via postsynthetic modifications of the as-synthesized particles. These cargoes are released upon the degradation of the NMOF frameworks, and the rate of cargo release was controlled by coating the NMOF particles with a silica shell. Potential utility of the new NMOF-based nanodelivery vehicles for optical imaging and anticancer therapy was demonstrated in vitro using HT-29 human colon adenocarcinoma cells. |
| Doi | 10.1021/ja906198y |
| Pmid | 19807179 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |